The formation and evolution of Liaohe Meso-Cenozoic Basin was controlled by the variation of different regional stress field. Based on the analysis of structural features, volcanic activities, sequence construction and so on, Liaohe Basin has experienced the period of dextral transtensional stress field in Late Jurassic-Early Cretaceous, Middle and Late Paleocene, Late Eocene, Miocene, and also the period of sinistral compresso-shear stress field in Late Cretaceous, Early Paleocene, Early and Middle Eocene, Oligocene, Pliocene.  The variation of regional stress field can be genetically interpreted by the rotation speed variation of the earth and its impact on the movement of lithosphere plate and deep processes of the earth, it is also related to the earlier structural feature and boundary of the basin. This variation results not only in the cyclicity of basin evolution, also in the formation of multiple oil bearing sequence in Meso-Cenozoic in Liaohe Basin and adjacent area.