Integration of sedimentologic and sequence stratigraphic interpretations of the Nkporo Group has provided the basis for a basin-wide framework for prediction of potential source, seal and reservoir rocks in the Anambra Basin, Nigeria. Lithofacies and biostratigraphic data show that the Nkporo Group in the Anambra Basin contains three main facies associations (fluvio-deltaic facies, estuarine central basin/shallow shelf facies and estuarine channel fill facies) that determine the reservoir containers, flow units and seals. The units are arranged to form two stratigraphic sequences represented by the Nkporo Shale-Owelli Sandstone and Owelli Sandstone-Enugu Shale successions, respectively. The transgressive systems tract in each sequence comprises coarse-grained fluvio-deltaic sandstone and an overlying open marine black carbonaceous mud rock. The highstand systems tracts comprise delta front deposits with average porosity, permeability and net-to-gross values estimated in the ranges of 30%, 3000 md and 0.9, respectively. The fluvio-deltaic and delta front facies which are encased in organically rich estuarine central basin/shallow shelf mud rocks are likely the potential reservoirs. Trapping capacity is enhanced by the presence of several N-S trending normal faults, and other microstructures related to the post-Santonian tensional regime in the Benue. The new information presented in this paper on potential seal, source and reservoir lithofacies within the Nkporo Group should serve as a useful contribution to the geological modelling of reservoirs within the Late Cretaceous-Paleocene succession in the Anambra Basin.