实用肿瘤学杂志 ›› 2015, Vol. 29 ›› Issue (1): 65-68.doi: 10.11904/j.issn.1002-3070.2015.01.014

• 综述 • 上一篇    下一篇

转铁蛋白-转铁蛋白受体抗肿瘤作用研究进展

陈玥琦1, 刘毅敏2, 张定林2   

  1. 1.第三军医大学学员旅15营(重庆 400038);
    2.第三军医大学基础部化学教研室
  • 收稿日期:2014-06-03 出版日期:2015-02-28 发布日期:2015-03-06
  • 通讯作者: 张定林,E-mail:zh18108@163.com
  • 作者简介:陈玥琦,男,(1995-),本科,从事肿瘤医学及骨科方面的研究

Research progress of transferrin and transferrin receptor on anti-tumor effect

CHEN Yueqi1,LIU Yimin2,ZHANG Dinglin2   

  1. 1.The Third Military Medical University Company 15,Chongqing 400038,China;
    2.Department of Chemistry,College of Pharmacy
  • Received:2014-06-03 Online:2015-02-28 Published:2015-03-06

摘要: 转铁蛋白(Transferrin,Tf)与转铁蛋白受体(Transferrin receptor,TfR)抗肿瘤作用显著,它们广泛存在于人体中。Tf参与铁的代谢,TfR干扰铁的代谢,控制铁的吸收,与转铁蛋白组成复合物诱导肿瘤细胞凋亡。Tf与TfR的结合,共同通过维持铁代谢,调节细胞生长与代谢和肿瘤细胞的代谢。本文就转铁蛋白-转铁蛋白受体在抗肿瘤方面的作用进行综述。

Abstract: The transferrrin(Tf)and the transferrin receptor(TfR)are effective anti tumor agents which exist widely in human body.The Tf takes an important role in iron metabolism,while the TfR disturbs iron metabolism and controls the iron absorbing.The compound of Tf and TfR can induce tumor cells apoptosis.Therefore,the combination of Tf and TfR can inhibit tumor growth efficiently.In addition,it is also good for anti tumor indirectly by taking Tf/TfR as target and using artemisinin.This article will review and summarize the anti tumor effect of transferrin and transferrin receptor.

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