青少年分化型甲状腺癌131I治疗的临床观察

doi:10.11904/j.issn.1002-3070.2015.03.001

实用肿瘤学杂志 ›› 2015, Vol. 29 ›› Issue (3): 193-196.doi: 10.11904/j.issn.1002-3070.2015.03.001

• 论著 • 下一篇

青少年分化型甲状腺癌¹³¹I治疗的临床观察

王迪¹, 何月涵², 王兴华¹, 于红波¹, 王玉君¹, 崔亚利¹

1.哈尔滨医科大学附属肿瘤医院核医学科(哈尔滨 150081);
2.哈尔滨医科大学生物信息科学与技术学院

收稿日期:2015-03-14 出版日期:2015-06-28 发布日期:2015-06-25
通讯作者: 崔亚利 E-mail:yalicui68@126.com
作者简介:王迪,女,(1981-),硕士,主管技师,从事肿瘤核医学的研究
基金资助:
黑龙江省卫生厅科研课题(2012-672)

Clinical observation of ¹³¹I in treatment of adolescents with differentiated thyroid carcinoma

WANG Di¹,HE Yuehan²,WANG Xinghua¹,YU Hongbo¹,WANG Yujun¹,CUI Yali¹

1.Department of Nuclear Medicine,The Affiliated Tumor Hospital of Harbin Medical University,Harbin 150081,China;
2.College of Bioinformatics Science and Technology,Harbin Medical University

Received:2015-03-14 Online:2015-06-28 Published:2015-06-25

摘要/Abstract

摘要：

目的探讨青少年分化型甲状腺癌的临床特点及¹³¹I治疗的临床疗效。方法回顾性分析2011年1月—2013年1月收治的181例分化型甲状腺癌患者的临床资料及随访结果,其中包括青少年患者(21岁及以下)36例,非青少年患者(21岁以上)145例,所有患者均进行¹³¹I治疗,并进行随访。结果青少年组的淋巴结转移和远处转移发生率均高于非青少年组(P＜0.05)。青少年组患者¹³¹I治疗的有效率为91.7%,非青少年组患者有效率为82.1%。青少年组患者随访期内未发现¹³¹I治疗引起肺纤维化、生长发育异常和继发肿瘤等不良事件发生。结论青少年分化型甲状腺癌更易发生局部淋巴结转移或远处转移,¹³¹I治疗青少年分化型甲状腺癌是一种安全有效的方法。

关键词: ¹³¹I, 甲状腺癌, 青少年, 临床观察

Abstract:

Objective To investigate the clinical characteristics and effect of the ¹³¹I therapy in the adolescents with differentiated thyroid carcinoma.Methods The clinical and follow up data of 181 patients with differentiated thyroid carcinoma who received initial ¹³¹I treatment from January 2011 to January 2013 were retrospectively analyzed.There were 36 cases of adolescent patients(21 years old or younger),and 145 cases of adult patients(More than 21 years old).Results The incidence of lymph node metastasis and distant metastasis in adolescent group were higher than that in the non-adolescent group(P＜0.05).The effective rate of adolescent patients with ¹³¹I treatment was 91.7%,and the effective rate was 82.1% in non-adolescent group.No pulmonary fibrosis,abnormity of growth and secondary malignancies were found during follow-up.Conclusion Adolescent patients with differentiated thyroid cancer are more likely to occur local lymph node metastasis or distant metastasis.¹³¹I therapy is an effective and safe method for young patients with differentiated thyroid carcinoma.

Key words: ¹³¹I, Thyroid carcinoma, Adolescent, Clinical observation

中图分类号:

R730.55

王迪¹, 何月涵², 王兴华¹, 于红波¹, 王玉君¹, 崔亚利¹. 青少年分化型甲状腺癌¹³¹I治疗的临床观察[J]. 实用肿瘤学杂志, 2015, 29(3): 193-196.

WANG Di,HE Yuehan,WANG Xinghua,YU Hongbo,WANG Yujun,CUI Yali. Clinical observation of ¹³¹I in treatment of adolescents with differentiated thyroid carcinoma[J]. PRACTICAL ONCOLOGY JOURNAL, 2015, 29(3): 193-196.

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青少年分化型甲状腺癌¹³¹I治疗的临床观察

Clinical observation of ¹³¹I in treatment of adolescents with differentiated thyroid carcinoma

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