长链非编码RNA在结直肠癌中的研究进展

doi:10.11904/j.issn.1002-3070.2015.03.016

实用肿瘤学杂志 ›› 2015, Vol. 29 ›› Issue (3): 263-266.doi: 10.11904/j.issn.1002-3070.2015.03.016

长链非编码RNA在结直肠癌中的研究进展

黄东宁¹, 梁小娜²综述, 陈罡²审校

1.广西医科大学第四附属医院肿瘤科/广西柳州市工人医院(柳州 545005);
2.广西医科大学第一附属医院病理科

收稿日期:2014-12-08 出版日期:2015-06-28 发布日期:2015-06-25
通讯作者: 陈罡 E-mail:chen_gang_triones@163.com
作者简介:黄东宁,男,(1973-),硕士,副主任医师,从事肿瘤放射治疗及化学治疗的研究

Progress in the study of lncRNA in the colorectal cancer

HUANG Dongning¹,LIANG Xiaona²,CHEN Gang²

1.Department of Oncology,The Fourth Affiliated Hospital of Guangxi Medical University&Liuzhou Worker′s Hospital,Liuzhou 545005,China;
2.Department of Pathology,The First Affiliated Hospital of Guangxi Medical University

Received:2014-12-08 Online:2015-06-28 Published:2015-06-25

摘要/Abstract

摘要：

长链非编码RNAs(Long non-coding RNAS,lncRNAs)是一类不编码蛋白质,长度大于200个核苷酸的RNA。结直肠癌的发生发展与lncRNA的异常表达密切相关。本文结合近年来国内外的文献报道,对lncRNA在结直肠癌中的表达情况及作用机制做一综述,以期为临床诊断和靶向治疗提供可能的依据。

关键词: 长链非编码RNA, 结直肠癌, 基因表达调节, 作用机制

Abstract:

Long non-coding RNA(lncRNA)is a group of RNAs that exceed 200nt in length without protein coding capacity.The tumorigenesis and progression of colorectal carcinoma relate to the aberrant expression of lncRNAs closely.In this review,we summarize researches in the current status of lncRNAs in human colorectal carcinoma to provide potential evidences for future diagnosis and gene therapies.

Key words: LncRNA, Colorectal neoplasms, Gene expression regulation, Mechanisms

中图分类号:

R735.3

黄东宁¹, 梁小娜²综述, 陈罡²审校. 长链非编码RNA在结直肠癌中的研究进展[J]. 实用肿瘤学杂志, 2015, 29(3): 263-266.

HUANG Dongning,LIANG Xiaona,CHEN Gang. Progress in the study of lncRNA in the colorectal cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2015, 29(3): 263-266.

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长链非编码RNA在结直肠癌中的研究进展

Progress in the study of lncRNA in the colorectal cancer

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