LncRNA在结直肠癌中的研究进展

doi:10.11904/j.issn.1002-3070.2015.04.015

实用肿瘤学杂志 ›› 2015, Vol. 29 ›› Issue (4): 355-358.doi: 10.11904/j.issn.1002-3070.2015.04.015

LncRNA在结直肠癌中的研究进展

刘欣综述,于志伟审校

哈尔滨医科大学附属肿瘤医院(哈尔滨 150081)

收稿日期:2015-02-27 出版日期:2015-08-27 发布日期:2015-08-27
通讯作者: 于志伟 E-mail::yuzw1974@hotmail.com
作者简介:刘欣,男,(1988-),硕士研究生,从事大肠癌临床治疗和基础的研究
基金资助:
国家自然科学基金(81272703)

The research development of LncRNA in colerectal cancer

LIU Xin,YU Zhiwei

Department of Colorectal Cancer,The Affiliated Tumor Hospital of Harbin Medical University,Harbin 150081,China

Received:2015-02-27 Online:2015-08-27 Published:2015-08-27

摘要/Abstract

摘要： 随着基因研究的进步,现已发现长链非编码RNA(Long non-coding RNA,LncRNA)在很多肿瘤的发生发展中起到关键的调节作用,其自身的各个片段能具有各不相同的调节效果;某些LncRNA甚至能在多种肿瘤中起到不同的调控作用。那么诸多新近发现的LncRNA在结直肠癌的表达情况如何？本文就LncRNA在结直肠癌中的研究进展做一综述。

关键词: 结直肠癌, LncRNA, 研究进展

Abstract: With the progress of genetic studies,it has been found that long non-coding RNA(LncRNA)in many regulations which play a key role in development of tumor.Its own individual pieces can also have different adjustive effects|some LncRNA can even have different regulation and controlling effect in a variety of tumor.How the newly discovered LncRNA expression in colorectal cancer? This review mainly outlines the research development of LncRNA in colerectal cancer in brief.

Key words: Colorectal cancer, LncRNA, Research development

中图分类号:

刘欣,于志伟. LncRNA在结直肠癌中的研究进展[J]. 实用肿瘤学杂志, 2015, 29(4): 355-358.

LIU Xin,YU Zhiwei. The research development of LncRNA in colerectal cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2015, 29(4): 355-358.

参考文献

1 Siegel R,Ward E,Brawley O,et al.Cancer statistics,2011:The impact of eliminating socioeconomic and racial disparities on premature cancer deaths[J].CA Cancer Clin,2011,61(4):212-236.
2 Kanthan R,Senger JL,Kanthan SC.Molecular events in primary and metastatic colorectal carcinoma:a review[J].Pathol Res Int,2012,2012,597497.
3 Wang,W,Li,Y,Zhang,X,et al.Evaluating the significance of expression of CEA mRNA and levels of CEA and its related proteins in colorectal cancer patients[J].Surg Oncol,2014,109(5):440-444.
4 Pichler M,Ress AL,Winter E,et al.MiR-200a regulates epithelial to mesenchymal transition-related gene expression and determines prognosis in colorectal cancer patients[J].Br J Cancer,2014,110(6):1614-1621.
5 Stotz M,Pichler M,Absenger G,et al.The preoperative lymphocyte to monocyte ratio predicts clinical outcome in patients with stage III colon cancer[J].Br J Cancer,2014,110(2):435-440.
6 Szkandera J,Pichler M,Absenger G,et al.A functional germline variant in GLI1 implicates hedgehog signaling in clinical outcome of stage II and III colon carcinoma patients[J].Clin Cancer Res,2014,20(6):1687-1697.
7 ENCODE Project Consortium.An integrated encyclopedia of DNA elements in the human genome[J].Nature,2012,489(7414):57-74.
8 Gupta RA,Shah N,Wang KC,et al.Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis[J].Nature,2010,464(7291):1071-1076.
9 Wang KC,Chang HY.Molecular mechanisms of long noncoding RNAs[J].Mol Cell,2011,43:904-914.
10 Tay Y,Rinn J,Pandolfi,PP.The multilayered complexity of ceRNA crosstalk and competition[J].Nature,2014,505(7483):344-352.
11 Li J,Xuan Z,Liu C.Long non-coding RNAs and complex human diseases[J].Int J Mol Sci,2013,14(9):18790-18808.
12 Takahashi Y,Sawada G,Kurashige J,et al.Amplification of PVT-1 is involved in poor prognosis via apoptosis inhibition in colorectal cancers[J].Br J Cancer,2014,110(1):164-171.
13 Ji P,Diederichs S,Wang W,et al.MALAT-1,a novel noncoding RNA,and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer[J].Oncogene,2003,22(39):8031-8041.
14 Ling H,Spizzo R,Atlasi Y,et al.CCAT2,a novel noncoding RNA mapping to 8q24,underlies metastatic progression and chromosomal instability in colon cancer[J].Genome Res,2013,23(9):1446-1461.
15 Qiu M,Xu Y,Yang X,et al.CCAT2 is a lung adenocarcinoma-specific long non-coding RNA and promotes invasion of non-small cell lung cancer[J].Tumour Biol,2014,35(6):5375-5380.
16 Qi P,Xu MD,Ni SJ,et al.Down-regulation of ncRAN,a long non-coding RNA,contributes to colorectal cancer cell migration and invasion and predicts poor overall survival for colorectal cancer patients[J].Mol Carcinog,2014.
17 Ge X,Chen Y,Liao X,et al.Overexpression of long noncoding RNA PCAT-1 is a novel biomarker of poor prognosis in patients with colorectal cancer[J].Med Oncol,2013,30(2):588.
18 Prensner JR,Iyer MK,Balbin OA,et al.Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1,an unannotated lincRNA implicated in disease progression[J].Nat Biotechnol.2011,29(8):742-749.
19 Pomerantz MM,Ahmadiyeh N,Jia L,et al.The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer[J].Nat Genet,2009,41(8):882-884.
20 Li L,Sun R,Liang Y,et al.Association between polymorphisms in long non-coding RNA PRNCR1 in 8q24 and risk of colorectal cancer[J].J Exp Clin Cancer Res,2013,32,104.
21 黄东宁,梁小娜,陈罡.长链非编码RNA在结直肠癌中的研究进展[J].实用肿瘤学杂志,2015,29(3):263-266.
22 吴杨佳子,高玉艳,张艳桥.精氨酸酶在结直肠癌中的研究进展[J].实用肿瘤学杂志,2013,27(5):460-463.

[1]	方琳, 刘超, 张纯慧, 张艳桥. 转移性结直肠癌维持治疗的研究现状与治疗策略[J]. 实用肿瘤学杂志, 2019, 33(2): 173-178.
[2]	佟广海, 田洋, 吴华星. 脂质组学在结直肠癌研究中的应用[J]. 实用肿瘤学杂志, 2019, 33(2): 179-192.
[3]	刘恒辰, 张新宇. Toll样受体信号通路作为结直肠癌潜在治疗靶点的研究进展[J]. 实用肿瘤学杂志, 2019, 33(2): 188-192.
[4]	刘宏涛, 张彤彤综述, 刘雁军审校. 肥胖与结直肠癌发病机制的研究进展[J]. 实用肿瘤学杂志, 2018, 32(5): 464-467.
[5]	王志, 刘忠卫, 曾雪芸, 隋明洁, 廖静怡, 李月欢, 黄卫东, 刘国祥. 基于EQ-5D-5L的结直肠癌癌前病变患者健康相关生命质量研究[J]. 实用肿瘤学杂志, 2018, 32(4): 320-326.
[6]	崔雪阳, 邢承忠. 液体活检在结直肠癌领域的研究及应用现状[J]. 实用肿瘤学杂志, 2018, 32(4): 367-370.
[7]	李文琪, 耿敬姝. RAS/RAF突变与MSI状态在结直肠癌治疗中的研究进展[J]. 实用肿瘤学杂志, 2018, 32(4): 371-376.
[8]	范宁宁, 耿敬姝. 长链非编码RNA MEG3在人胶质瘤细胞中的表达及作用研究[J]. 实用肿瘤学杂志, 2018, 32(3): 219-223.
[9]	杨钊, 赵世光. 长链非编码RNA CASC2抑制肿瘤发生发展的研究概况[J]. 实用肿瘤学杂志, 2018, 32(2): 179-183.
[10]	张姗姗, 吴华星审校. 代谢组学在结直肠癌诊断中的应用[J]. 实用肿瘤学杂志, 2017, 31(6): 573-576.
[11]	孙丽娜, 赵晓迪综述, 卢瑗瑗, 王新审校. LncRNA与胃肠道肿瘤化疗耐药的研究进展[J]. 实用肿瘤学杂志, 2017, 31(5): 448-453.
[12]	王东亮,戚宁,牟冠男,张月桂. 结直肠癌肿瘤微环境中调节性T细胞CD39、CD73亚群及二者双阳性亚群的临床意义[J]. 实用肿瘤学杂志, 2017, 31(4): 329-334.
[13]	郝小军，王传卓，赵相轩，辛鹤，刘兆玉. miR-34a对结肠癌细胞SW480增殖、迁移和侵袭能力的影响及机制探讨[J]. 实用肿瘤学杂志, 2017, 31(3): 193-198.
[14]	张明, 朱信强, 丁闯, 孔令永, 陈焰. 结直肠癌患者术后预后营养指数在预后评估中的应用[J]. 实用肿瘤学杂志, 2017, 31(2): 131-136.
[15]	苗大壮, 佟金学, 贾云鹤. 加速康复外科理念在腹腔镜辅助结直肠癌手术围手术期中的应用价值[J]. 实用肿瘤学杂志, 2017, 31(2): 137-141.

LncRNA在结直肠癌中的研究进展

The research development of LncRNA in colerectal cancer

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价