SPOCK1蛋白结构和功能与肿瘤的研究进展

doi:10.11904/j.issn.1002-3070.2015.04.021

摘要/Abstract

摘要： 睾丸蛋白聚糖1(SPOCK1)是一种细胞外基质糖蛋白,能够抑制组织蛋白酶的活性及促进低亲和力钙的结合。SPOCK1对哺乳动物的发育至关重要,它不仅调节细胞之间以及细胞与基质之间的相互作用,还与细胞的迁移和增殖有关。目前证实SPOCK1的过表达可以促进肿瘤的发生和发展,提示它有可能成为一个新的抗肿瘤治疗靶点。本文现对SPOCK1分子结构、生物学功能及其与肿瘤的关系等方面进行综述。

关键词: 睾丸蛋白聚糖1, 蛋白聚糖, 细胞外基质, 肿瘤

Abstract: Testicular proteoglycan 1(SPOCK1),a kind of extracellular matrix glycoprotein,can inhibit the activity of cathepsin and promotes the combination of low affinity for calcium.SPOCK1 is essential to the development of mammals.It not only regulates cell,and the interactions between cells and matrix are also related to cell migration and proliferation.Currently,SPOCK1is confirmed that expression can promote the occurrence and development of tumor,suggesting it could be a new anti-tumor target.This article is to review SPOCK1 molecular structure,biological function and its relationship with tumor.

Key words: SPOCK1, Proteoglycan, Extracellular matrix, Tumor

中图分类号:

R730.43

国昊楠,彭士云. SPOCK1蛋白结构和功能与肿瘤的研究进展[J]. 实用肿瘤学杂志, 2015, 29(4): 380-384.

GUO Haonan,PENG Shiyun. The research progression on SPOCK1 and tumor[J]. PRACTICAL ONCOLOGY JOURNAL, 2015, 29(4): 380-384.

参考文献

1 Yamamoto A,Uchiyama K,Nara T,et al.Structural abnormalities of corpus callosum and cortical axonal tracts accompanied by decreased anxiety-like behavior and lowered sociability in spock3-mutant mice[J].Dev Neurosci,2013,36(5):381-395.
2 Li Y,Chen L,Chan THM,et al.SPOCK1 is regulated by CHD1L and blocks apoptosis and promotes HCC cell invasiveness and metastasis in [J].Gastroenterology,2013,144(1):179-191.
3 Leja J,Essaghir A,Essand M,et al.Novel markers for enterochromaffin cells and gastrointestinal neuroendocrine carcinomas[J].Modern Pathology,2009,22(2):261-272.
4 Wlazlinski A,Engers R,Hoffmann MJ,et al.Downregulation of several fibulin genes in prostate cancer[J].Prostate,2007,67(16):1770-1780.
5 Miao L,Wang Y,Xia H,et al.SPOCK1 is a novel transforming growth factor-β target gene that regulates lung cancer cell epithelial-mesenchymal transition[J].Biochem Biophys Res Commun,2013,440(4):792-797.
6 Kim HP,Han SW,Song SH,et al.Testican-1-mediated epithelial-mesenchymal transition signaling confers acquired resistance to lapatinib in HER2-positive gastric cancer[J].Oncogene,2014,33(25):3334-3341.
7 Charbonnier F,Perin JP,Mattei MG,et al.Genomic organization of the human SPOCK gene and its chromosomal localization to 5q31[J].Genomics,1998,48(3):377-380.
8 Tai IT,Tang MJ.SPARC in cancer biology:its role in cancer progression and potential for therapy[J].Drug Resistance Updates,2008,11(6):231-246.
9 BaSalamah MAM,Marr HS,Duncan AW,et al.Testican in Human Blood[J].Biochem Biophys Res Commun,2001,283(5):1083-1090.
10 Vanhoutte D,van Almen GC,Van Aelst L NL,et al.Matricellular proteins and matrix metalloproteinases mark the inflammatory and fibrotic response in human cardiac allograft rejection[J].Eur Heart J,2013,34(25):1930-1941.
11 Kohfeldt E,Maurer P,Vannahme C,et al.Properties of the extracellular calcium binding module of the proteoglycan testican[J].FEBS Letters,1997,414(3):557-561.
12 Marr HS,Basalamah MA,Bouldin TW,et al.Distribution of testican expression in human brain[J].Cell Tissue Res,2000,302(2):139-144.
13 Zhang L.Glycosaminoglycan(GAG)biosynthesis and GAG-binding proteins[J].Prog Mol Biol Transi Sci,2010,93(5):1-17.
14 Berger EA,McClellan SA,Barrett RP,et al.Testican-1 promotes resistance against pseudomonas aeruginosa-induced keratitis through regulation of MMP-2 expression and activation[J].Invest Ophthalmol Vis Sci,2011,52(8):5339-5346.
15 Cifuentes-Diaz C,Alliel PM,Charbonnier F,et al.Regulated expression of the proteoglycan SPOCK in the neuromuscular system[J].Mechanisms of Development,2000,94(1):277-282.
16 Marr HS,Edgell CJS.Testican-1 inhibits attachment of Neuro-2a cells[J].Matrix Biology,2003,22(3):259-266.
17 Dhamija R,Graham JM,Smaoui N,et al.Novel de novo SPOCK1 mutation in a proband with developmental delay,microcephaly and agenesis of corpus callosum[J].Eur J Med Genet,2014,57(4):181-184.
18 Takahata T,Hashikawa T,Tochitani S,et al.Differential expression patterns of OCC1-related,extracellular matrix proteins in the lateral geniculate nucleus of macaque monkeys[J].J Chem Neuroanat,2010,40(2):112-122.
19 Edgell CJS,BaSalamah MA,Marr HS.Testican-1:a differentially expressed proteoglycan with protease inhibiting activities[J].Int Rev Cytol,2004,236(4):101-122.
20 Kawamata H,Furihata T,Omotehara F,et al.Identification of genes differentially expressed in a newly isolated human metastasizing esophageal cancer cell line,T.Tn‐AT1,by cDNA microarray[J].Cancer Science,2003,94(8):699-706.
21 Lankelma JM,Voorend DM,Barwari T,et al.Cathepsin L,target in cancer treatment?[J].Life Sciences,2010,86(7):225-233.
22 Hartmann U,Hülsmann H,Seul J,et al.Testican-3:a brain-specific proteoglycan member of the BM-40/SPARC/osteonectin family[J].Journal of Neurochemistry,2013,125(3):399-409.
23 Sage J,Malleèvre F,Barbarin-Costes F,et al.Binding of chondroitin 4-sulfate to cathepsin S regulates its enzymatic activity[J].Biochemistry,2013,52(37):6487-6498.
24 Li Y,Chan HM,Chen L,et al.Identification and characterization of SPOCK1 in HCC development[J].Cancer Research,2011,71(8 Suppl):3057-3063.
25 Cheng W,Su Y,Xu F,et al.CHD1L:a novel oncogene[J].Molecular Cancer,2013,12(51):9403-9403.
26 Chen L,Hu L,Chan THM,et al.Chromodomain helicase/adenosine triphosphatase DNA binding protein 1-like(CHD1l)gene suppresses the nucleus-to-mitochondria translocation of nur77 to sustain hepatocellular carcinoma cell survival[J].Hepatology,2009,50(1):122-129.
27 Yang C,Fischer-Keo R,Schlechter T,et al.Plakophilin 1-deficient cells upregulate SPOCK1:implications for prostate cancer progression[J].Tumor Biology,2015,(4):1-11.
28 Kusakabe M,Kutomi T,Watanabe K,et al.Identification of G0S2 as a gene frequently methylated in squamous lung cancer by combination of in silico and experimental approaches[J].International Journal of Cancer,2010,126(8):1895-1902.
29 Seo DC,Sung JM,Cho HJ,et al.Gene expression profiling of cancer stem cell in human lung adenocarcinoma A549 cells[J].Mol Cancer,2007,6(1):75.
30 Ni XY,Sui HX,Liu Y,et al.TGF-β of lung cancer microenvironment upregulates B7H1 and GITRL expression in dendritic cells and is associated with regulatory T cell generation[J].Oncology Reports,2012,28(2):615-621.
31 Reticker-Flynn NE,Malta DFB,Winslow MM,et al.A combinatorial extracellular matrix platform identifies cell-extracellular matrix interactions that correlate with metastasis[J].Nature Communications,2012,3:1122-1132.
32 Oberg K,Akerstrm G,Rindi G,et al.Neuroendocrine gastroenteropancreatic tumours:ESMO Clinical Practice Guidelines for diagnosis,treatment and follow-up[J].Annals of Oncology,2010,21(suppl 5):v223-227.
33 berg K,Castellano D.Current knowledge on diagnosis and staging of neuroendocrine tumors[J].Cancer and Metastasis Reviews,2011,30(1):3-7.
34 Clevers H,Nusse R.Wnt/β-catenin signaling and disease[J].Cell,2012,149(6):1192-1205.
35 Shu YJ,Weng H,Ye YY,et al.SPOCK1 as a potential cancer prognostic marker promotes the proliferation and metastasis of gallbladder cancer cells by activating the PI3K/AKT pathway[J].Molecular Cancer,2015,14(1):12.
36 Theocharis AD,Gialeli C,Bouris P,et al.Cell-matrix interactions:focus on proteoglycan-proteinase interplay and pharmacological targeting in cancer[J].Febs Journal,2014,281(22):5023-5042(20).

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