心理社会危险因素与甲状腺癌的相关性研究

doi:10.11904/j.issn.1002-3070.2015.05.007

实用肿瘤学杂志 ›› 2015, Vol. 29 ›› Issue (5): 414-419.doi: 10.11904/j.issn.1002-3070.2015.05.007

心理社会危险因素与甲状腺癌的相关性研究

丁兆明, 陈琢, 陈丽丽

哈尔滨医科大学附属肿瘤医院甲状腺外科(哈尔滨 150081)

收稿日期:2015-05-04 出版日期:2015-10-28 发布日期:2015-10-30
通讯作者: 丁兆明,E-mail:chring723@163.com
作者简介:丁兆明,男,(1988-),硕士,住院医师,从事甲状腺癌发病机制的研究

The relationship between thyroid carcinoma and psychosocial risk factors

DING Zhaoming, CHEN Zhuo, CHEN Lili

Department of Thyroid Surgery,The Affiliated Tumor Hospital of Harbin Medical University,Harbin 150081,China

Received:2015-05-04 Online:2015-10-28 Published:2015-10-30

摘要/Abstract

摘要： 目的探讨生活事件、情绪状态及个性行为特征等心理社会应激因素与甲状腺癌发病的相关性,为更有效的防治甲状腺癌提供科学依据。方法采用以医院为基础的病例-对照研究,经病理确诊为甲状腺乳头状癌的病例组102人和病理为甲状腺良性疾病的对照组114人,采用团体用心理社会应激调查表测试其生活事件、情绪反应及应对方式等三个方面。结果多因素Logistic回归结果显示劳累过度(OR=3.198)、子女前途问题(OR=7.785)、忧郁(OR=6.014)、焦虑(OR=18.853)、将情绪压到心底(OR=7.836)是甲状腺癌发病的危险因素;而愉快的情绪状态(OR=0.054)和能够尽快忘掉不愉快的应对方式(OR=0.093)是甲状腺癌发病的保护性因素。结论某些负性生活事件、消极的情绪及应对方式与甲状腺癌的发病相关,而保持心情愉快会在一定程度上降低甲状腺癌发病的几率。

关键词: 甲状腺癌, 心理应激, 病例-对照研究

Abstract: Objective To investigate the relationship between thyroid carcinoma and psychosocial risk factors.Methods A hospital based case-controlled study of thyroid carcinoma was conducted.Cases were pathologically confirmed as primary papillary thyroid carcinoma.Both 102 cases and 114 controls were tested by the PSSG scale.Results Multivariate conditional logistic regression analysis showed that overworking,children′s future,depress,anxiety,and like to suppress their emotions could increase the risk of thyroid carcinoma,pleasing emotion and forget unhappy as soon as possible might prevent the thyroid carcinoma.Conclusion Psychosocial risk factors are important in the onset and progression of the thyroid carcinoma.

Key words: Thyroid carcinoma, Psychosocial stress, Case control study

中图分类号:

R736.1

丁兆明, 陈琢, 陈丽丽. 心理社会危险因素与甲状腺癌的相关性研究[J]. 实用肿瘤学杂志, 2015, 29(5): 414-419.

DING Zhaoming, CHEN Zhuo, CHEN Lili. The relationship between thyroid carcinoma and psychosocial risk factors[J]. PRACTICAL ONCOLOGY JOURNAL, 2015, 29(5): 414-419.

参考文献

1 Jemal A,Bray F,Center MM,et al.Global cancer statistics[J].CA Cancer J Clin,2011,61(2):69-90.
2 于家伟,管强,孔令宇,等.Fascin蛋白在甲状腺乳头状癌中的表达及其临床意义[J].实用肿瘤学杂志,2011,25(2):129-132.
3 Xing M.Molecular pathogenesis and mechanisms of thyroid cancer[J].Nat Rev Cancer,2013,13(3):184-199.
4 Fang CY,Egleston BL,Ridge JA,et al.Psychosocial functioning and vascular endothelial growth factor in patients with head and neck cancer[J].Head Neck,2014,36(8):1113-1119.
5 Buckley MM,O′Mahony SM,O′Malley D.Convergence of neuro-endocrine-immune pathways in the pathophysiology of irritable bowel syndrome[J].World J Gastroenterol,2014,20(27):8846-8858.
6 Smith HR.Depression in cancer patients:Pathogenesis,implications and treatment(Review)[J].Oncol Lett,2015,9(4):1509-1514.
7 Ginzburg K,Wrensch M,Rice T,et al.Breast cancer and psychosocial factors:early stressful life events,social support,and well-being[J].Psychosomatics,2008,49(5):407-412.
8 Haun MW,Sklenarova H,Villalobos M,et al.Depression,anxiety and disease-related distress in couples affected by advanced lung cancer[J].Lung Cancer,2014,86(2):274-280.
9 Courtney JG,Longnecker MP,Peters RK.Psychosocial aspects of work and the risk of colon cancer[J].Epidemiology,1996,7(2):175-181.
10 Bultz BD,Waller A,Cullum J,et al.Implementing routine screening for distress,the sixth vital sign,for patients with head and neck and neurologic cancers[J].J Natl Compr Canc Netw,2013,11(10):1249-1261.
11 姜乾金.心理社会应激因素的综合评估初探[J].中国行为医学科学,1998,7(3):182-184.
12 李丹丹,胡付兰,朱琳,等.心理社会危险因素与大肠癌的相关性研究[J].实用肿瘤学杂志,2012,26(4):328-335.
13 Clement SC,Kremer LC,Links TP,et al.Is outcome of differentiated thyroid carcinoma influenced by tumor stage at diagnosis[J].Cancer Treat Rev,2015,41(1):9-16.
14 Buchmann L,Ashby S,Cannon RB,et al.Psychosocial distress in patients with thyroid cancer[J].Otolaryngol Head Neck Surg,2015,152(4):644-649.
15 Min JA,Yoon S,Lee CU,et al.Psychological resilience contributes to low emotional distress in cancer patients[J].Support Care Cancer,2013,21(9):2469-2476.
16 Han X,Lin CC,Li C,et al.Association between serious psychological distress and health care use and expenditures by cancer history[J].Cancer,2015,121(4):614-622.
17 Biondi M,Costantini A,Parisi A.Can loss and grief activate latent neoplasia? A clinical case of possible interaction between genetic risk and stress in breast cancer[J].Psychother Psychosom,1996,65(2):102-105.
18 Buchmann L,Conlee J,Hunt J,et al.Psychosocial distress is prevalent in head and neck cancer patients[J].Laryngoscope,2013,123(6):1424-1429.
19 Bierhaus A,Wolf J,Andrassy M,et al.A mechanism converting psychosocial stress into mononuclear cell activation[J].Proc Natl Acad Sci USA,2003,100(4):1920-1925.
20 Jehn CF,Kuehnhardt D,Bartholomae A,et al.Biomarkers of depression in cancer patients[J].Cancer,2006,107(11):2723-2729.
21 Dantzer R,O′Connor JC,Freund GG,et al.From inflammation to sickness and depression:when the immune system subjugates the brain[J].Nat Rev Neurosci,2008,9(1):46-56.

[1]	孔繁巍综述, 赵长久审校. 分化型甲状腺癌碘131治疗后的外周血细胞改变[J]. 实用肿瘤学杂志, 2018, 32(5): 476-479.
[2]	教玉颖综述, 付鹏审校. 甲状腺癌与干扰素-γ、白介素-6关系的研究进展[J]. 实用肿瘤学杂志, 2017, 31(1): 88-92.
[3]	程卫,赵华. 重组人促甲状腺激素辅助¹³¹I在儿童和青少年分化型甲状腺癌的临床研究[J]. 实用肿瘤学杂志, 2016, 30(4): 309-313.
[4]	冯卓颖, 鹿瑶, 苏雁欣, 都杨. Logistic回归模型在超声评价甲状腺结节良恶性及淋巴转移的应用研究[J]. 实用肿瘤学杂志, 2015, 29(5): 385-389.
[5]	孙冀, 苗素生, 裴荣综述, 毛雄辉审校. RET基因在肿瘤中的研究现状和展望[J]. 实用肿瘤学杂志, 2015, 29(5): 467-470.
[6]	王迪¹, 何月涵², 王兴华¹, 于红波¹, 王玉君¹, 崔亚利¹. 青少年分化型甲状腺癌¹³¹I治疗的临床观察[J]. 实用肿瘤学杂志, 2015, 29(3): 193-196.
[7]	李丹丹, 胡付兰, 朱琳, 王彝白娜, 刘宇鹏, 陈王洋, 崔滨滨, 赵亚双. 心理社会危险因素与大肠癌的相关性研究[J]. 实用肿瘤学杂志, 2012, 26(4): 328-335.
[8]	田淞宇, 秦华东, 石铁锋, 刘垚, 孙宇. 乳腺癌与甲状腺癌相关性的探讨[J]. 实用肿瘤学杂志, 2011, 25(4): 333-335.
[9]	焦明秀综述, 崔亚利审校. 肿瘤乏氧显像在预测甲状腺癌内放疗疗效的临床应用[J]. 实用肿瘤学杂志, 2009, 23(6): 593-596.
[10]	陈征综述, 赵雪松审校. p16、p27和Cyclin D1在分化型甲状腺癌的表达研究^△[J]. 实用肿瘤学杂志, 2009, 23(4): 389-393.
[11]	王玉君;赵彦辉;崔亚利. 99mTc-MIBI全身显像在131I治疗分化型甲状腺癌转移灶中的应用价值[J]. 实用肿瘤学杂志, 2008, 22(04): 337-338.
[12]	王翠芳;孙洁;滕猛;宦大为. RET、HBME-1和Ki67在甲状腺良、恶性肿瘤中的表达[J]. 实用肿瘤学杂志, 2007, 21(05): 427-429.
[13]	高虹;丛琦;全成实;郭晓峰. 甲状腺癌组织中凋亡相关蛋白Fas,FasL,Bcl-2和Bax的表达及意义[J]. 实用肿瘤学杂志, 2005, 19(04): 273-275.
[14]	何洪江;贾深汕. 甲状腺癌组织中诱导型一氧化氮合酶与CD105的表达及其意义[J]. 实用肿瘤学杂志, 2004, 18(06): 435-437.
[15]	王琤;周义林;张军盛;徐慧琴. 99mTc-MIBI显像对甲状腺结节良恶性的鉴别诊断价值[J]. 实用肿瘤学杂志, 2003, 17(03): 195-196.

心理社会危险因素与甲状腺癌的相关性研究

The relationship between thyroid carcinoma and psychosocial risk factors

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价