局部晚期喉癌3DCRT与IMRT放疗计划的剂量学对比

doi:10.11904/j.issn.1002-3070.2015.05.008

实用肿瘤学杂志 ›› 2015, Vol. 29 ›› Issue (5): 420-423.doi: 10.11904/j.issn.1002-3070.2015.05.008

局部晚期喉癌3DCRT与IMRT放疗计划的剂量学对比

孙迪, 云惟康, 葛晓峰, 陈林, 胡洪涛

哈尔滨医科大学附属肿瘤医院(哈尔滨 150081)

收稿日期:2015-03-04 出版日期:2015-10-28 发布日期:2015-10-30
通讯作者: 胡洪涛,E-mail:huht9099@sohu.com
作者简介:孙迪,男,(1985-),硕士,住院医师,从事肿瘤放疗相关的研究
基金资助:
哈尔滨市科技创新人才研究专项资金项目(2009RFQXS015)

Dosimetric comparison with conventional radiation therapy and intensity modulated radiation therapy for locally advanced laryngeal carcinoma

SUN Di, YUN Weikang, GE Xiaofeng, CHEN Lin, HU Hongtao

The Affiliated Tumor Hospital of Harbin Medical Universiy,Harbin 150081,China

Received:2015-03-04 Online:2015-10-28 Published:2015-10-30

摘要/Abstract

摘要： 目的利用ECLIPSE计划系统对局部晚期喉癌适形放疗(3DCRT)和逆向调强适形放疗(IMRT)计划作剂量学比较,评估不同照射方法的优缺点。方法选择6例病理证实的局部晚期喉癌患者,用ECLIPSE对每例患者分别作出3DCRT和IMRT计划。根据靶区V95%、D5%、D95%、靶区最大值、最小值及平均值和正常组织受量D50、D33、D5、Dmax和Dmean来比较这两种计划剂量学的差异。结果两种不同计划中的靶区分布中,GTV和GTVnd差别不大,但对于亚临床区CTV和某些正常组织有统计学差异。结论对局部晚期喉癌原发灶及阳性淋巴结,3DCRT和IMRT计划均有较好覆盖。但在亚临床病灶方面,IMRT比3DCRT包含靶区更好一些,且IMRT减少了腮腺正常组织的照射剂量。

关键词: 局部晚期喉癌, 适形放疗, 逆向调强适形放疗, 剂量学对比

Abstract: Objective To compare the differences between conventional radiation therapy(3DCRT)and intensity modulated radiation therapy(IMRT)for locally advanced laryngeal carcinoma patients by ECLIPSE treatment planning system.Methods Six locally advanced laryngeal carcinoma patients′ treatment plans were designed as IMRT and 3DCRT according to ECLIPSE treatment planning system,respectively.The following values were measured,such as V95%、D5%、D95%、Dmin and D mean of the target volume,and the D50,D33,D5,Dmax and Dmean of normal tissues.Results The dose coverage rate of GTV and GTVnd in the IMRT plan was compared to ECLIPSE treatment planning system with no statistical differences.However,there were obvious difference in CTV and some normal tissues.Conclusion Both IMRT and 3DCRT have good coverage to primary tumor and metastatic lymph nodes.IMRT can spare the parotid from high dose irradiation.

Key words: Locally advanced laryngeal carcinoma, Conventional radiation therapy, Intensity modulated radiation therapy, Dosimetric comparison

中图分类号:

孙迪, 云惟康, 葛晓峰, 陈林, 胡洪涛. 局部晚期喉癌3DCRT与IMRT放疗计划的剂量学对比[J]. 实用肿瘤学杂志, 2015, 29(5): 420-423.

SUN Di, YUN Weikang, GE Xiaofeng, CHEN Lin, HU Hongtao. Dosimetric comparison with conventional radiation therapy and intensity modulated radiation therapy for locally advanced laryngeal carcinoma[J]. PRACTICAL ONCOLOGY JOURNAL, 2015, 29(5): 420-423.

参考文献

1 罗京伟,殷蔚伯,余子豪,等.喉癌、下咽癌[M].北京:中国协和医科大学出版社,2008:383-426.
2 Forastiere AA,Zhang Q,Weber RS,et al.Long-term results of RTOG 91-11:a comparison of three nonsurgical treatment strategies to preserve the larynx in patients with locally advanced larynx cancer [J].J Clin Oncol,2013,31(7):845-852.
3 Lefebvre JL,Pointreau Y,Rolland F,et al.Induction chemotherapy followed by either chemoradiotherapy or bioradiotherapy for larynx preservation:the TREMPLIN randomized phase II study [J].J Clin Oncol,2013,31(7):853-859.
4 Holsinger FC,Funk E,Roberts DB,et al.Conservation laryngeal surgery versus total laryngectomy for radiation failure in laryngeal cancer [J].Head Neck,2006,28(9):779-784.
5 Yao M,Dornfeld KJ,Buatti JM,et al.Intensity-modulated radiation treatment for head-and-neck squarnous cell carcinoma-The University of Iowa experience [J].Int J Radiat Oncol Biol Phys,2005,63(2):410-421.
6 Studer G,Lutolf UM,Glanzmann C.Locoregional failure analysis in head-and-neck cancer patients treated with IMRT [J].Strahlenther Onkol,2007,183(8):417-423.
7 Wu Q,Manning M,Schmidt-Ullrich R,et al.The potential for sparing of parotids and escalation of biologically effective dose with intensity-modulated radiation treatments of head and neck cancers:a treatment design study [J].Int J Radiat Oncol Biol Phys,2000,46(1):195-205.
8 Clemente S,Wu B,Sanguineti G,et al.Smart are-based volumetric modulated arc therapy for oropharyngeal cancer;A dosimetric comparison with both intensity-modulated radiation therapy and helical tomotherapy [J].Int J Radiat Oncol Biol Phys,2011,80(4):1248-1255.
9 Van′t Riet A,Mak ACA,Moerland MA,et al.A conformation number to quantify the degree of conformality in brachytherapy and external beam irradiation:application to the prostate [J].Int J Rad Oncol Biol Phys,1997,37(3):731-736.
10 Feuvret L,Noel G,Mazeron JJ,et al.Conformity index:a review [J].Int J Rad Oncol Biol Phys,2006,64(2):333-342.
11 Guerrero Urbano MT,Clark CH,Kong C,et al.Target volume definition for head and neck intensity modulated radiotherapy:pre-clinical evaluation of PARSPORT trial guidelines [J],Clin Oncol,2007,19(8):604-613.
12 Cardinale RM,Bendict SH,Wu QW,et al.A comparison of three stereotactic radiotherapy techniques:ARCS Vs.noncoplanar fixed fields VS.intensity modulation [J].Int J Radiat Oncol Biol Phys,1998,42(2):431-436.
13 Cooper JS,Fu K,Marks J,et al.Late effects of radiation therapy in the head and neck region [J].Int J Radiat Oncol Biol Phys,1995,31(5):1141-1164.

[1]	徐建宇, 徐向英, 许庆勇, 胡松柳, 刘珊珊, 卢姗. 局部晚期非小细胞肺癌不同放化疗模式的临床研究[J]. 实用肿瘤学杂志, 2010, 24(1): 48-52.
[2]	栾瑾微, 尤庆山. 不同方法治疗晚期胰腺癌的临床疗效观察[J]. 实用肿瘤学杂志, 2009, 23(4): 328-331.
[3]	马景光, 邢丽娜, 刘晓, 董广璐, 刘晓滨, 魏星. 卡培他滨联合奈达铂同步放化疗宫颈复发癌[J]. 实用肿瘤学杂志, 2009, 23(4): 346-348.
[4]	郭化东;姜秀玲;石磊;王滨. 颅内胶质瘤的立体定向放射治疗[J]. 实用肿瘤学杂志, 2007, 21(04): 363-365.
[5]	杨芝萍;李金瑞. 三维适形放疗技术在恶性肿瘤治疗中的应用[J]. 实用肿瘤学杂志, 2006, 20(06): 519-520,.
[6]	纪卫;朱琳燕;方坚强. 同步三维适形放化疗治疗直肠癌术后复发的疗效观察[J]. 实用肿瘤学杂志, 2006, 20(06): 487-488,.
[7]	周永涛;李慧灵;刘秀英. 健择配合放射治疗晚期胰腺癌的临床研究[J]. 实用肿瘤学杂志, 2006, 20(06): 541-541,509.
[8]	刘建国;韩秋菊. 肺癌适形放疗与常规放疗致心肌酶谱改变的对比分析[J]. 实用肿瘤学杂志, 2006, 20(03): 221-222.
[9]	黄赖机;张秀萍;李健;邓瑾;P.LABAT;I.NATALIE. 三维适形放疗技术在局限性前列腺癌治疗中的应用[J]. 实用肿瘤学杂志, 2005, 19(05): 374-376.
[10]	孙德宇;何文贵;陈琦. Ⅲ期非小细胞肺癌三维适形放疗近期疗效观察[J]. 实用肿瘤学杂志, 2005, 19(03): 217-218.
[11]	张旭红;谢香玲;王刚. 三维适形放疗同步化疗治疗非小细胞肺癌临床观察[J]. 实用肿瘤学杂志, 2005, 19(02): 133-135.
[12]	高媛. 颅内肿瘤三维适形放疗病人的临床护理[J]. 实用肿瘤学杂志, 2005, 19(01): 56-57.
[13]	徐向英;胡洪涛;王瑞芝;郭汝涛;张丽萍;白彦灵. Ⅰ、Ⅱ期乳腺癌保乳术后的三维适形调强放射治疗[J]. 实用肿瘤学杂志, 2004, 18(06): 419-421.
[14]	刘士新;赵玲;王福香. 38例癌性上腔静脉综合征放疗疗效分析[J]. 实用肿瘤学杂志, 2004, 18(04): 289-290.
[15]	王振峰;陈兴秀;徐方军;李强;杨焕莲;张素美;毕益明. 立体定向适形放疗晚期胰腺癌的临床研究[J]. 实用肿瘤学杂志, 2003, 17(03): 215-217.

局部晚期喉癌3DCRT与IMRT放疗计划的剂量学对比

Dosimetric comparison with conventional radiation therapy and intensity modulated radiation therapy for locally advanced laryngeal carcinoma

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价