肿瘤干细胞潜在标志物DCLK1在消化道恶性肿瘤中的研究进展

doi:10.11904/j.issn.1002-3070.2015.05.016

实用肿瘤学杂志 ›› 2015, Vol. 29 ›› Issue (5): 458-461.doi: 10.11904/j.issn.1002-3070.2015.05.016

肿瘤干细胞潜在标志物DCLK1在消化道恶性肿瘤中的研究进展

吕福莲, 高翔综述, 金艾顺审校

哈尔滨医科大学基础医学院免疫教研室(哈尔滨 150081)

收稿日期:2015-03-31 出版日期:2015-10-28 发布日期:2015-10-30
通讯作者: 金艾顺,E-mail:aishunjin@ems.hrbmu.edu.cn
作者简介:吕福莲,女,(1990-),硕士研究生,从事肿瘤靶向治疗的研究
基金资助:
教育部留学回国人员科研启动基金(3001301000098)

Functional characteristic research progress of DCLK1 as a potential biomarker in cancer stem cells for gastrointestinal onalignancies

LV Fulian, GAO Xiang, JIN Aishun

Department of Immunology,Harbin Medical University,Harbin 150081,China

Received:2015-03-31 Online:2015-10-28 Published:2015-10-30

摘要/Abstract

摘要： 肿瘤干细胞标志物的发现及应用对于肿瘤的预防和治疗有重要的意义。DCLK1是首次被发现只存在于肿瘤干细胞而不存在于正常干细胞的标志物。DCLK1在胃肠道癌、食道癌、胆管癌和神经胶质瘤等肿瘤细胞中均有表达,并且与肿瘤的发生发展和迁移复发都密切相关。尽管DCLK1作为肿瘤干细胞标志物还存在很多未知,但是DCLK1为肿瘤的靶向特异性治疗提供了一个新的发展前景。

关键词: DCLK1, 肿瘤干细胞, 消化道肿瘤, 靶向治疗, 预后预测

Abstract: The discovery and application of cancer stem cell markers have very important significance on tumor treatment and prevention.DCLK1 is discovered only in the cancer stem cell marker but not nomal stem cells for the first time.Some studies have shown that DCLK1 expression was detectded in gastrointestinal cancer,esophageal cancer,bile duct carcinoma and glioma.The expression of DCLK1 in tumor is closely related to tumor development,progression,and recurrenceand migration.Although DCLK1 remain to be known as cancer stem cell marker,it provides a new developing prospectives for tumor targeting specific treatment.

Key words: DCLK1, Neoplastic stem cells, Gastrointestinal tumor, Targeted therapy, Prognosis

中图分类号:

R73.5

吕福莲, 高翔综述, 金艾顺审校. 肿瘤干细胞潜在标志物DCLK1在消化道恶性肿瘤中的研究进展[J]. 实用肿瘤学杂志, 2015, 29(5): 458-461.

LV Fulian, GAO Xiang, JIN Aishun. Functional characteristic research progress of DCLK1 as a potential biomarker in cancer stem cells for gastrointestinal onalignancies[J]. PRACTICAL ONCOLOGY JOURNAL, 2015, 29(5): 458-461.

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肿瘤干细胞潜在标志物DCLK1在消化道恶性肿瘤中的研究进展

Functional characteristic research progress of DCLK1 as a potential biomarker in cancer stem cells for gastrointestinal onalignancies

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