新型接头蛋白XB130在恶性肿瘤中的研究进展

doi:10.11904/j.issn.1002-3070.2015.06.019

实用肿瘤学杂志 ›› 2015, Vol. 29 ›› Issue (6): 565-568.doi: 10.11904/j.issn.1002-3070.2015.06.019

新型接头蛋白XB130在恶性肿瘤中的研究进展

马铭, 杨芳, 陈公琰

哈尔滨医科大学附属肿瘤医院肿瘤内一科(哈尔滨 150081)

收稿日期:2015-08-16 出版日期:2015-12-28 发布日期:2015-12-28
通讯作者: 陈公琰,E-mail:chengongyan@163.com E-mail:chengongyan@163.com
作者简介:马铭,女,(1988-),硕士研究生,从事呼吸肿瘤的研究

Research of XB130,a novel adaptor protein in cancer

MA Ming, YANG Fang, CHEN Gongyan

Department of Breathing Tumor Internal Medicine,The Affiliated Tumor Hospital of Harbin Medical University,Harbin 150081,China

Received:2015-08-16 Online:2015-12-28 Published:2015-12-28

摘要/Abstract

摘要： 目前XB130作为一种新发现的接头蛋白,参与了细胞内多条信号转导通路,例如黏着斑激酶(FAK)/SRC信号通路、PI3K/Akt信号通路和MEK-ERK信号通路等。而且最近在多种肿瘤细胞中均发现XB130高表达,例如甲状腺癌、骨肉瘤、胃癌、食管癌和乳腺癌等,其在恶性肿瘤中的作用机制也日益引起重视。XB130是新发现的肿瘤癌基因,具有促进肿瘤细胞增殖、存活及致肿瘤形成的作用。本文就新型接头蛋白XB130在恶性肿瘤中的研究现状做一综述。

关键词: 接头蛋白, XB130, 肿瘤

Abstract: Currently,XB130 as a newly discovered characterized adaptor protein,it has been implicated as a substrate and regulator of many intracellular signal transduction,such as FAK/SRC,PI3K/Akt and MEK-ERK signaling and so on.It has been found that XB130 is high expression in many cell lines,for instance thyroid carcinoma,osteosarcoma,gastric cancer,esophageal cancer and breast cancer etc.The mechanism of XB130 in tumor is becoming increasingly attention.XB130 is recently attributed to be a new oncogene,and plays important roles in cell pro-liferation,cell survival and tumorigenesis.A deeper understanding of these mechanisms may lead to the discovery of XB130 as an important mediator in tumor development and as a novel therapeutic target for cancer.

Key words: Adaptor protein, XB130, Cancer

中图分类号:

马铭, 杨芳, 陈公琰. 新型接头蛋白XB130在恶性肿瘤中的研究进展[J]. 实用肿瘤学杂志, 2015, 29(6): 565-568.

MA Ming, YANG Fang, CHEN Gongyan. Research of XB130,a novel adaptor protein in cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2015, 29(6): 565-568.

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新型接头蛋白XB130在恶性肿瘤中的研究进展

Research of XB130,a novel adaptor protein in cancer

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