关键词: 重组人促甲状腺激素, ¹³¹I, 分化型甲状腺癌, 青少年

Abstract: Objective The study is mainly on the effect and outcome of ¹³¹I treatment for children and adolescents with differentiated thyroid cancer.Methods We compared the difference between rhTSH-aided radioiodine treatment and L-thyroxin withdrawal.Our study collected 87 patients in a retrospective study.In order to analysis the effect,we divided into two groups.The experimental group has 46 patients,and control check has 41 patients.We compared the basic characteristics and mortality in different groups by χ²-test,t-test and F-test based on data type.Results The thyroid stimulating hormone concentrations of experimental group patients have significant differences in the first,the third and the sixth day after the injected of rhTSH,the third day is the highest.The TSH concentration has significant difference between the two groups before ¹³¹I treatment(t=2.362,P=0.023).For the Tg(thyrobolulin)negative patients,Tg concentration in control check is higher than the third day after injected of rhTSH in the experiment group(1.5±1.2 vs. 0.7±1.4,P=0.034).Whole body image has been done by scintigraphic after 3~8 months of ¹³¹I treatment.Thirty four(84%)patients have no radioiodine uptake in experiment group,and 40(87%)patients have no radioiodine uptake in control check,there is no difference between the two groups(χ²=0.277,P=0.599).There is no difference between the two groups on the reason for retreatment(P=0.875).Conclusion The outcome of rhTSH-aided radioiodine treatment is similar to L-thyroxin withdrawal in short-term recurrences,and rhTSH-aided radioiodine treatment with ¹³¹I therapy for children and adolescents with DTC is a better method.

Key words: Recombinant human thyrotropin(rhTSH), ¹³¹I, Differentiated thyroid cancer(DTC), Adolescents