实用肿瘤学杂志 ›› 2016, Vol. 30 ›› Issue (4): 365-369.doi: 10.11904/j.issn.1002-3070.2016.04.014

• 综述 • 上一篇    下一篇

肾素-血管紧张素系统相关受体在乳腺癌中的研究进展

王婷 综述,陈雪松 审校   

  1. 哈尔滨医科大学附属肿瘤医院内四科(哈尔滨 150081)
  • 收稿日期:2016-04-14 出版日期:2016-08-10 发布日期:2016-08-19
  • 通讯作者: 陈雪松,E-mail:cxs1978@ems.hrbmu.edu.cn
  • 作者简介:王婷,女,(1990-),硕士研究生,从事乳腺癌侵袭和转移的研究
  • 基金资助:

    国家自然科学基金(81573001);黑龙江省教育厅项目(12541435);哈尔滨医科大学肿瘤医院科研基金(JJLX2014-02);黑龙江省中医管理局(ZQG-045)

Research progresses of Renin-angiotensin system receptors in breast cancer

WANG Ting,CHEN Xuesong   

  1. Department of Oncology,The Affiliated Tumor Hospital of Harbin Medical University,Harbin 150081,China
  • Received:2016-04-14 Online:2016-08-10 Published:2016-08-19

摘要:

近期研究表明,肾素-血管紧张素系统(Renin-angiotensin system,RAS)不仅在心血管系统方面起作用,而且在乳腺癌的发生和发展中也扮演着重要的角色。血管紧张素Ⅱ(Angiotensin Ⅱ,Ang Ⅱ)和血管紧张素1-7(Angiotensin 1-7,Ang1-7)是RAS的主要效应分子,它们通过作用于RAS相关受体,可分别促进和抑制乳腺癌的发生和发展。本文就RAS在乳腺癌中的相关研究加以总结,并探讨RAS相关受体靶向治疗药物在乳腺癌临床治疗中的潜在用途。

关键词: 肾素-血管紧张素系统, RAS相关受体, 乳腺癌

Abstract:

Recent studies had demonstrated that Renin-angiotensin system(RAS)plays an important role not only in the cardiovascular system,but also in the occurrence and development of breast cancer.Associated with RAS receptor,Angiotensin Ⅱ(Ang Ⅱ)and Angiotensin 1-7(Ang1-7)which are the major molecules of the RAS,respectively,promote or inhibit the occurrence and development of tumor.In this review,we summarize the current knowledge of the RAS in breast cancer,and discuss the potential application of RAS related receptors targeted drugs in the clinical treatment of breast cancer.

Key words: Renin-angiotensin system, RAS receptor, Breast cancer

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