NF-κB对大肠癌发生发展的影响及其相关治疗的研究现状

doi:10.11904/j.issn.1002-3070.2017.01.009

摘要/Abstract

摘要： NF-κB转录因子家族广泛存在于真核细胞中,调控着细胞的生存、生长和凋亡过程,参与炎症、免疫性疾病及肿瘤等疾病的发生与发展。在大肠癌的疾病进程中,NF-κB作为炎性因子介导慢性结肠炎症向癌症的转化。同时,它又能通过调控细胞周期而抑制细胞的凋亡,促进大肠癌的发生,并在化学药物治疗的过程中通过抑制凋亡而介导大肠癌细胞的多药耐药。研究发现一些中西药制剂能够直接或间接作用于NF-κB,抑制大肠癌的发生以及治疗过程中出现的多药耐药,这为大肠癌的治疗提供了新的思路与靶点。

关键词: NF-KappaB, 结肠炎症, 大肠癌, 耐药

Abstract: In eukaryotic cells,NF-κB transcription factor family regulates many processes like cell survival,growth,and apoptosis.It participates in the development of a variety of diseases,including inflammatory,immune disease,and cancer.As an inflammatory factor,NF-κB mediates the transformation of chronic colitis to cancer during the course of colorectal cancer.Furthermore,it could inhibit cell apoptosis through regulating cell cycles,which promotes the development of colorectal cancer and mediates the multidrug resistance of the tumor cells.Therefore,targeting NF-κB,a large number of preparations involved both Chinese and western medicine has been researched.The further research and the use of them may be an effective method to cure the colorectal cancer in clinical work.

Key words: NF-KappaB, Colitis, Colorectal neoplasm, Drug resistance

中图分类号:

R735.3

段佩雯, 赵苗苗综述, 王松坡审校. NF-κB对大肠癌发生发展的影响及其相关治疗的研究现状[J]. 实用肿瘤学杂志, 2017, 31(1): 43-47.

DUAN Peiwen, ZHAO Miaomiao, WANG Songpo. The recent advances in the research of NF-κB in the development and relevant treatment of the colorectal cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2017, 31(1): 43-47.

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