CBX与肿瘤关系的研究进展

doi:10.11904/j.issn.1002-3070.2017.02.014

摘要/Abstract

摘要： CBX蛋白(Chromobox protein homolog)是多梳蛋白家族(Polycomb group proteins,PcG)的重要成员,多梳蛋白家族是一种表观遗传调控复合物,以聚合转录抑制复合体PRCs的形式存在,可以通过修饰染色质对靶基因进行转录抑制,在调控细胞分化、衰老、死亡和肿瘤发生、转移中发挥着重要作用。CBX蛋白家族是经典型PRC1的重要成员,包括5个成员,CBX2、CBX4、CBX6、CBX7和CBX8,越来越多的证据表明它在肿瘤发生、发展中扮演重要角色。本篇综述阐述了目前关于CBX家族成员在肿瘤中的研究进展。

关键词: 多梳蛋白家族PcG, CBX蛋白家族, 肿瘤, 发生机制

Abstract: CBX protein(chromoboxin protein homolog)is an important member of PcG(polycombe group proteins)family protein,and PcG protein is an epigenetic regulatory complex that exists in the form of polymeric transcriptional inhibitory complexes PRCs.PcG protein can modify the target gene to transcript chromatin and plays an important role in stem cell differentiation and tumorigenesis and metastasis.The CBX protein family is an important member of the classic PRC1.Recent studies have focused on the different functions of CBX in stem cells,further demonstrating the composition and function of CBX.From more evidence,CBX plays an important role in tumorigenesis and development.This review summarizes the current advances in the study of CBX family members in tumors.

Key words: Polycomb group protein, Chromobox protein homolog, Tumors, Mechanism

中图分类号:

R73-3

曾凯(综述), 刘明(审校). CBX与肿瘤关系的研究进展[J]. 实用肿瘤学杂志, 2017, 31(2): 165-169.

ZENG Kai,LIU Ming. Research progress of CBX protein and tumor[J]. PRACTICAL ONCOLOGY JOURNAL, 2017, 31(2): 165-169.

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