肠道上皮细胞再生修复与恶性转化的研究现状

doi:10.11904/j.issn.1002-3070.2017.03.015

实用肿瘤学杂志 ›› 2017, Vol. 31 ›› Issue (3): 262-267.doi: 10.11904/j.issn.1002-3070.2017.03.015

肠道上皮细胞再生修复与恶性转化的研究现状

姜蒙综述，刘明审校

哈尔滨医科大学附属第四医院普外科(哈尔滨 150001)

收稿日期:2016-04-19 出版日期:2017-06-28 发布日期:2017-07-04
通讯作者: 刘明,E-mail:mLiu35@aliyun.com
作者简介:姜蒙,男,(1988-),硕士研究生,从事肠道肿瘤的研究

Self renewal,repair and malignant transformation of intestine epithelial cells

JIANG Meng,LIU Ming

The Fourth Affiliated of Harbin Medical University,Harbin 150001,China

Received:2016-04-19 Online:2017-06-28 Published:2017-07-04

摘要/Abstract

摘要： 肠黏膜慢性炎症是肠道肿瘤发展的重要组成部分。近期,对肠道肿瘤患者的高通量测序研究发现了一个潜在的、以伤口愈合和先天免疫基因过表达为特征的结肠癌分子亚型,它提示了一种可能依赖于炎症细胞和细胞因子的肿瘤发展机制,增强了我们对细胞恶性转化的理解,以及突出了抗炎在肿瘤治疗中的作用。本文将对正常的肠黏膜更新、伤口愈合和恶变的机制做一综述。

关键词: 肠上皮, 炎症损伤, 恶性转化

Abstract: Chronic inflammation of intestine mucosal has been considered as a critical component of colorectal cancer development.Recently,the studies based on high throughput sequencing of colorectal cancer patients released a potential molecular subtype of colorectal cancer,characterized by wound healing and innate immune genes.It suggests that a probably mechanism described by a subset of cells that may be dependent on inflammatory cells and cytokines of tumor development,extremely expanding our insight of cell malignant transformation,and highlight the anti-inflammation treatment.This article will review the normal mechanism of intestine mucosal renewal,wound healing and malignant transformation.

Key words: Intestine mucosal, Chronicinflammation, Malignant transformation

中图分类号:

R320.2710

姜蒙综述，刘明审校. 肠道上皮细胞再生修复与恶性转化的研究现状[J]. 实用肿瘤学杂志, 2017, 31(3): 262-267.

JIANG Meng,LIU Ming. Self renewal,repair and malignant transformation of intestine epithelial cells[J]. PRACTICAL ONCOLOGY JOURNAL, 2017, 31(3): 262-267.

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肠道上皮细胞再生修复与恶性转化的研究现状

Self renewal,repair and malignant transformation of intestine epithelial cells

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