基质蛋白对恶性肿瘤骨转移作用的研究进展

doi:10.11904/j.issn.1002-3070.2017.03.020

摘要/Abstract

摘要： 恶性肿瘤骨转移发病率较高,且严重影响患者的生存质量,故明确其发生机制对恶性肿瘤的预防和治疗都有重要意义。目前已证实肿瘤微环境在原发肿瘤迁移过程中起重要作用,而基质蛋白是骨髓微环境的重要组成成分。最新的研究发现基质蛋白可通过促进肿瘤细胞的增殖、侵袭和转移,进而参与骨转移过程。本文就基质蛋白在恶性肿瘤骨转移过程中的调控作用加以综述。

关键词: 基质蛋白, 骨髓基质, 骨转移

Abstract: The incidence of bone metastases in malignant tumors is high,and seriously affected the life quality of patients.It is clear that the mechanism of the prevention and treatment of malignant tumors are of great significance.It has been confirmed that tumor microenvironment plays an important role in the migration of primary tumors,and the matrix protein is an important component of bone marrow microenvironment.In recent years,the latest study has been found that matrix proteins can be involved in the process of bone metastasis by promoting tumor cell proliferation,invasion and metastasis.In this paper,the role of matrix proteins in the process of bone metastasis of malignant tumors was reviewed.

Key words: Matrix proteins, Bone marrow matrix, Bone metastases

中图分类号:

R730

简立智，王天娇综述，吴瑾审校. 基质蛋白对恶性肿瘤骨转移作用的研究进展[J]. 实用肿瘤学杂志, 2017, 31(3): 285-288.

JIAN Lizhi,WAGN Tianjiao,WU Jin. Research progress of matrix protein in bone metastasis of malignant tumor[J]. PRACTICAL ONCOLOGY JOURNAL, 2017, 31(3): 285-288.

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