CST1基因在肿瘤中的研究进展

doi:10.11904/j.issn.1002-3070.2017.04.013

实用肿瘤学杂志 ›› 2017, Vol. 31 ›› Issue (4): 359-362.doi: 10.11904/j.issn.1002-3070.2017.04.013

CST1基因在肿瘤中的研究进展

崔逸峰,宋瑞鹏,郭晓综述,陆朝阳审校

哈尔滨医科大学附属第一医院肝脏外科,肝脾外科教育部重点实验室(哈尔滨 150001)

收稿日期:2017-03-15 出版日期:2017-08-20 发布日期:2017-08-23
通讯作者: 陆朝阳,E-mail:lzy76772005@163.com
作者简介:崔逸峰,男,(1988-),硕士研究生,从事肝脏疾病的诊疗研究。
基金资助:
国家自然科学基金(81602058)

Research progress of CST1 gene in tumor

CUI Yifeng,SONG Ruipeng,GUO Xiao,LU Zhaoyang

Department of Hepatic Surgery,The First Affiliated Hospital of Harbin Medical University,Key Laboratory of Hepatosplenic Surgery,Ministry of Education,Harbin 150001,China

Received:2017-03-15 Online:2017-08-20 Published:2017-08-23

摘要/Abstract

摘要： 半胱氨酸蛋白酶抑制剂(Cystatin,CST)是对半胱氨酸蛋白酶具有抑制作用的一类蛋白质,广泛分布于人体体液和分泌液中。目前研究表明CST超家族与肿瘤之间具有密切联系,其中,半胱氨酸蛋白酶抑制剂SN(Cystatin SN)为CST1基因所表达的产物,在多种肿瘤中表达异常。但其对肿瘤的发生发展以及侵袭转移等作用的具体机制目前尚不明确。本文通过对近年来国内外相关文献进行回顾性分析,对CST1基因在肿瘤中的研究进展做一综述。

关键词: 半胱氨酸蛋白酶抑制剂, 半胱氨酸蛋白酶抑制剂SN, 肿瘤

Abstract: Cystatin Cystatin(CST)is a class of proteins that inhibit cysteine proteases and are widely distributed in human body fluid and secretion.The present study shows that the CST superfamily is closely related to the tumor,in which the cysteine protease inhibitor SN is the product expressed by the CST1 gene and is abnormal expression in various tumors.However,its occurrence and development of tumor as well as effects of invasion and metastasis on the specific mechanism is not yet clear.In this paper,we retrospectively analyze the related studies in recent years and review the progress of CST1 gene in tumor.

Key words: CST, Cystatin SN, Tumor

中图分类号:

崔逸峰,宋瑞鹏,郭晓,陆朝阳. CST1基因在肿瘤中的研究进展[J]. 实用肿瘤学杂志, 2017, 31(4): 359-362.

CUI Yifeng,SONG Ruipeng,GUO Xiao,LU Zhaoyang. Research progress of CST1 gene in tumor[J]. PRACTICAL ONCOLOGY JOURNAL, 2017, 31(4): 359-362.

参考文献

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CST1基因在肿瘤中的研究进展

Research progress of CST1 gene in tumor

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