代谢组学在结直肠癌诊断中的应用

doi:10.11904/j.issn.1002-3070.2017.06.018

实用肿瘤学杂志 ›› 2017, Vol. 31 ›› Issue (6): 573-576.doi: 10.11904/j.issn.1002-3070.2017.06.018

• 综述 • 上一篇

代谢组学在结直肠癌诊断中的应用

张姗姗, 吴华星审校

哈尔滨医科大学附属肿瘤医院腔镜科(哈尔滨 150081)

收稿日期:2017-07-04 出版日期:2017-12-28 发布日期:2018-01-02
通讯作者: 吴华星,E-mail:107178265@qq.com
作者简介:张姗姗,女,(1986),硕士研究生,从事代谢组学在结直肠癌诊断中的研究。

Aplication of metabolomics in the diagnosis of colorectal cancer

ZHANG Shanshan, WU Huaxing

Department of Endoscopy,Harbin Medical University Cancer Hospital,Harbin 150081,China

Received:2017-07-04 Online:2017-12-28 Published:2018-01-02

摘要/Abstract

摘要： 结直肠癌是严重威胁人类健康的常见恶性肿瘤之一,代谢组学能有效地补充传统检查手段的不足。代谢组学通过检测肿瘤患者组织、血液及尿液中的代谢物,寻找差异代谢物从而发现新的特异性的肿瘤标志物。与正常细胞相比,肿瘤细胞存在着多个异常代谢通路。找出其代谢变化,为深入探讨结直肠癌生物标志物及其相关机制奠定了基础,对诊断和个体化治疗有着深远的意义。

关键词: 结直肠癌, 诊断, 代谢组学, miRNA

Abstract: Colorectal cancer,a common malignant tumor,is a serious threat to human health.Metabolomics can effectively solve the shortcomings of the traditional ways of inspection.Metabolomics develop different metabolites to find new specific tumor markers by detecting metabolites in tissues,blood and urine of cancer patients.Compared with normal cells,tumor cells exist a number of abnormal metabolic pathways.It lays the foundation for further study of biomarkers of colorectal cancer by finding out its metabolic changes.It also shows important significance for diagnosis,evaluation of efficacy and prognosis and individual treatment.

Key words: Colorectal cancer, Diagnosis, Metabolomics, miRNA

中图分类号:

R735.3⁺4

张姗姗, 吴华星审校. 代谢组学在结直肠癌诊断中的应用[J]. 实用肿瘤学杂志, 2017, 31(6): 573-576.

ZHANG Shanshan, WU Huaxing. Aplication of metabolomics in the diagnosis of colorectal cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2017, 31(6): 573-576.

参考文献

1 胡正青,林夏珍,郭明.代谢组学研究技术进展[J].中国现代应用药学,2010,27(6):485-490.
2 Garritano S,Selvaggi F,Spampinato MG.Simultaneous minimally invasive treatment of colorectal neoplasm with synchronous liver metastasis[J].Med Sci,2016,6(6):1-7.
3 Esposito K,Chiodini P,Colao A,et al.Metabolic syndrome and risk of cancer[J].Diabetes Care,2012,35(11):2402-2411.
4 Di L M,Travaglio E,Altomare DF.New strategies for colorectal cancer screening[J].World J Gastroenterol,2013,19(12):1855-1860.
5 Zhang A,Sun H,Yan G,et al.Metabolomics in diagnosis and biomarker discovery of colorectal cancer[J].Cancer Letters,2014,345(1):17-21.
6 戚文娟,田雪娇,周长江.代谢组学在结直肠癌中的研究进展[J].医学与哲学,2013,34(12):62-64.
7 Huang S,Chong N,Lewis NE,et al.Novel personalized pathway-based metabolomics models reveal key metabolic pathways for breast cancer diagnosis[J].Genome Medicine,2016,8(1):554-561.
8 Whiteside TL.The tumor microenvironment and its role in promoting tumor growth[J].Oncogene,2008,27(45):5904-5912.
9 吴卉,花荣,陈锦先.代谢组学在结直肠肿瘤中的应用进展[J].胃肠病学,2010,15(8):499-501.
10 Ludwig C,Ward DG,Martin A,et al.Fast targeted multidimensional NMR metabolomics of colorectal cancer[J].Magn Reson Chem,2010,47(1):68-73.
11 Yuan T,Xu T,Huang J,et al.Tissue metabonomic phenotyping for diagnosis and prognosis of human colorectal cancer[J].Scientific Reports,2016,6(4):188-196.
12 Schipani E,Maes C,Carmeliet G,et al.Regulation of osteogenesis-angiogenesis coupling by HIFs and VEGF[J].J Bone Miner Res,2009,24(8):1347-1353.
13 Montrose DC,Zhou XK,Kopelovich L,et al.Metabolic profiling,a noninvasive approach for the detection of experimental colorectal neoplasia[J].Cancer Prevention Research,2012,5(12):1358-1367.
14 Denkert C,Budczies J,Weichert W,et al.Metabolite profiling of human colon carcinoma-deregulation of TCA cycle and amino acid turnover[J].Molecular Cancer,2008,7(1):72-87.
15 Kühn T,Floegel A,Sookthai D,et al.Higher plasma levels of lysophosphatidylcholine 18:0 are related to a lower risk of common cancers in a prospective metabolomics study[J].BMC Medicine,2016,14(1):1-9.
16 Ke J,Lin Y,Ruge F,et al.Implication of metastasis suppressor gene,Kiss-1 and its receptor Kiss-1R in colorectal cancer[J].BMC Cancer,2014,14(1):723-734.
17 Wang Y,Hu Z,Liang J,et al.A tandem repeat of human telomerase reverse transcriptase(hTERT)and risk of breast cancer development and metastasis in Chinese women[J].Carcinogenesis,2008,29(6):1197-1201.
18 Gertler R,Rosenberg R,Stricker D,et al.Telomere length and human telomerase reverse transcriptase expression as markers for progression and prognosis of colorectal carcinoma[J].Med Sci,2004,22(10):1807-1814.
19 伍世钢.hTERT和E2F-1蛋白在结直肠癌组织中的表达及其临床意义[D].广州:暨南大学,2016.
20 Urayama S.Pancreatic cancer early detection:Expanding higher-risk group with clinical and metabolomics parameters[J].World J Gastroenterol,2015,21(6):1707-1717.
21 王健.miR-552和miR-592在结直肠肿瘤中表达的研究[D].宁夏:宁夏医科大学,2015.
22 Alexander L,Francesc B,Shen Y,et al.Fecal microRNAs as novel biomarkers for colon cancer screening[J].Cancer Epidemiol Biomarkers Prev,2010,19(7):1766-1774.
23 杨静.检测粪便脱落细胞中miR-135b表达筛查结直肠进展期腺瘤及TNMⅠ期Ⅱ期癌的意义研究[D].太原:山西医科大学,2016.
24 徐学虎,黎淑玲,吴小兵,等.miR-4770作为结直肠癌的诊断标志物研究[J].实用医学杂志,2015,31(18):2994-2997.
25 靳慧芳.miR-30a对结直肠癌细胞侵袭和转移的影响及其相关分子机制的初步研究[D].郑州:郑州大学,2015.

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代谢组学在结直肠癌诊断中的应用

Aplication of metabolomics in the diagnosis of colorectal cancer

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