长链非编码RNA在胃癌中的调控机制及中药对其作用的研究概况

doi:10.11904/j.issn.1002-3070.2018.01.009

实用肿瘤学杂志 ›› 2018, Vol. 32 ›› Issue (1): 47-52.doi: 10.11904/j.issn.1002-3070.2018.01.009

长链非编码RNA在胃癌中的调控机制及中药对其作用的研究概况

余嘉惠¹, 刘煊^1,2, 李琦², 陆烨¹ 综述, 岳小强¹ 审校

1.上海长征医院中医科(上海 200003);
2.上海中医药大学附属曙光医院肿瘤科,中西医结合肿瘤研究所

收稿日期:2017-06-21 出版日期:2018-02-20 发布日期:2018-03-07
通讯作者: 岳小强,E-mail:yuexiaoqiang@163.com
作者简介:余嘉惠,女,(1993-),硕士研究生,从事中西医结合防治消化道肿瘤临床和研究的工作。
基金资助:
国家自然科学基金青年项目(81603434);国家博士后基金资助项目(1613)

Regulative mechanism of long non-coding RNA in gastric cancer and its role in traditional Chinese medicine

YU Jiahui¹, LIU Xuan^1,2, LI Qi², LU Ye¹, YUE Xiaoqiang¹

1.Department of Traditional Chinese Medicine,Shanghai Changzheng Hospital,Shanghai,200003;
2.Department of TCM Oncology,Shuguang Hospital Affiliated to Shanghai University,Combine Traditional Chinese and Western Medicine Tumor Research Institute

Received:2017-06-21 Online:2018-02-20 Published:2018-03-07

摘要/Abstract

摘要： 长链非编码RNA(Long noncoding RNA,LncRNA)是一类不能编码翻译蛋白质的长度大于200个核苷酸的RNA,它能够通过与DNA、RNA或蛋白质结合,参与X染色体沉默、染色质修饰、转录激活、转录干扰等调控过程。近年来越来越多研究证实,其在胃癌的发生发展和侵袭转移中发挥作用。与此同时,以LncRNA为靶点的中药抗胃癌恶性行为研究逐年增多,本文介绍了LncRNA在胃癌恶性行为调控中的作用机制及以此为靶点的中药治疗前景。

关键词: 长链非编码RNA, 胃癌, 中药, 综述

Abstract: Long non-coding RNA(LncRNA)is a class of RNA that cannot encode translated proteins with more than 200 nucleotides in length.It can be involved in the regulation of X chromosome silencing,chromatin modification,transcriptional activation,transcriptional interference and other regulatory processes by binding to DNA,RNA or proteins.In recent years,more and more studies have confirmed that LncRNA plays an important role in the occurrence,development,invasion and metastasis of gastric cancer.At the same time,many studies have demonstrated LncRNA as the target of traditional Chinese medicine for the development and progression of anti-gastric cancer.This review introduces the mechanism of LncRNA in the development and progression of gastric cancer,and as a target for traditional Chinese medicine treatment prospects.

Key words: Long noncoding RNA, Gastric Cancer, Chinese Medicine, Review

中图分类号:

R735.7

余嘉惠, 刘煊, 李琦, 陆烨, 岳小强. 长链非编码RNA在胃癌中的调控机制及中药对其作用的研究概况[J]. 实用肿瘤学杂志, 2018, 32(1): 47-52.

YU Jiahui, LIU Xuan, LI Qi, LU Ye, YUE Xiaoqiang. Regulative mechanism of long non-coding RNA in gastric cancer and its role in traditional Chinese medicine[J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(1): 47-52.

参考文献

1 Kapranov P,Cheng J,Dike S,et al.RNA maps reveal new RNA classes and a possible function for pervasive transcription[J].Science,2007,316(5830):1484-1488.
2 Bánfai B,Jia H,Khatun J,et al.Long noncoding RNAs are rarely translated in two human cell lines[J].Genome Res,2012,22(9):1646-1657.
3 Clark MB,Amaral PP,Schlesinger FJ,et al.The reality of pervasive transcription[J].PLoS Biol,2011,9(7):e1000625.
4 Dinger ME,Amaral PP,Mercer TR,et al.Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation[J].Genome Res,2008,18(9):1433-1445.
5 Riquelme I,Saavedra K,Espinoza JA,et al.Molecular classification of gastric cancer:Towards a pathway-driven targeted therapy[J].Oncotarget,2015,6(28):24750-24779.
6 Mercer TR,Dinger ME,Mattick JS.Long non-coding RNAs:Insights into functions[J].Nat Rev Genet,2009,10(3):155-159.
7 Derrien T,Johnson R,Bussotti G,et al.The GENCODE v7 catalog of human long noncoding RNAs:Analysis of their gene structure,evolution,and expression[J].Genome Res,2012,22(9):1775-1789.
8 Niazi F,Valadkhan S.Computational analysis of functional long noncoding RNAs reveals lack of peptide-coding capacity and parallels with 3′ UTRs[J].RNA,2012,18(4):825-843.
9 Novikova IV,Hennelly SP,Sanbonmatsu KY.Sizing up long non-coding RNAs:Do LncRNAs have secondary and tertiary structure?[J].Bioarchitecture,2012,2(6):189-199.
10 Xu TP,Huang MD,Xia R,et al.Decreased expression of the long non-coding RNA FENDRR,is associated with poor prognosis in gastric cancer and FENDRR,regulates gastric cancer cell metastasis by affecting fibronectin1 expression[J].J Hematol Oncol,2014,7:63.
11 Huang MD,Chen WM,Qi FZ,et al.Long non-coding RNA ANRIL is upregulated in hepatocellular carcinoma and regulates cell proliferation by epigenetic silencing of KLF2[J].J Hematol Oncol,2015,8:50.
12 Ling H,Spizzo R,Atlasi Y,et al.CCAT2,a novel noncoding RNA mapping to 8q24,underlies metastatic progression and chromosomal instability in colon cancer[J].Genome Res,2013,23(9):1446-1461.
13 Yang XJ,Huang CQ,Peng CW,et al.Long noncoding RNA HULC promotes colorectal carcinoma progression through epigenetically repressing NKD2 expression[J].Gene,2016,592(1):172-178.
14 Nie F,Yu X,Huang M,et al.Long noncoding RNA ZFAS1 promotes gastric cancer cells proliferation by epigenetically repressing KLF2 and NKD2 expression[J].Oncotarget,2017,8(24):38227-38238.
15 He X,Tan X,Wang X,et al.C-Myc-activated long noncoding RNA CCAT1 promotes colon cancer cell proliferation and invasion[J].Tumour Biol,2014,35(12):12181-12188.
16 Yang F,Xue X,Zheng L,et al.Long non-coding RNA GHET1 promotes gastric carcinoma cell proliferation by increasing c-Myc mRNA stability[J].FEBS J,2014,281(3):802-813.
17 Xu TP,Liu XX,Xia R,et al.SP1-induced upregulation of the long noncoding RNA TINCR regulates cell proliferation and apoptosis by affecting KLF2 mRNA stability in gastric cancer[J].Oncogene,2015,34(45):5648-5661.
18 Xu C,Shao Y,Xia T,et al.LncRNA-AC130710 targeting by miR-129-5p is upregulated in gastric cancer and associates with poor prognosis[J].Tumour Biol,2014,35(10):9701-9706.
19 Qi P,Xu MD,Shen XH,et al.Reciprocal repression between TUSC7 and miR-23b in gastric cancer[J].Int J Cancer,2015,137(6):1269-1278.
20 Shao Y,Ye M,Li Q,et al.LncRNA-RMRP promotes carcinogenesis by acting as a miR-206 sponge and is used as a novel biomarker for gastric cancer[J].Oncotarget,2016,7(25):37812-37824.
21 Liu G,Xiang T,Wu QF,et al.Long noncoding RNA H19-derived miR-675 enhances proliferation and invasion via RUNX1 in gastric cancer cells[J].Oncol Res,2016,23(3):99-107.
22 Liu X,Jiao TL,Wang YZ,et al.Long non-coding RNA GAS5 acts as a molecular sponge to regulate miR-23a in gastric cancer[J].Int J Clin Exp Patnol,2016,9(11):11412-11419.
23 Zhang Y,Chen Z,Li MJ,et al.Long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 regulates the expression of Gli2 by miR-202 to strengthen gastric cancer progression[J].Biomed Pharmacother,2017,85:264-271.
24 Ji TT,Huang X,Jin J,et al.Inhibition of long non-coding RNA TUG1 on gastric cancer cell transference and invasion through regulating and controlling the expression of miR-144/c-Met axis[J].Asian Pac J Trop Med,2016,9(5):508-512.
25 Fang Q,Chen XY,Zhi X.Long non-coding RNA(LncRNA)urothelial carcinoma associated 1(UCA1)increases multi-drug resistance of gastric cancer via downregulating miR-27b[J].Med Sci Monit,2016,22:3506-3513.
26 Hu Y,Wang J,Qian J,et al.Long noncoding RNA GAPLINC regulates CD44-dependent cell invasiveness and associates with poor prognosis of gastric cancer[J].Cancer Res,2014,74(23):6890-6902.
27 Yan J,Dang Y,Liu S,et al.LncRNA HOTAIR promotes cisplatin resistance in gastric cancer by targeting miR-126 to activate the PI3K/AKT/MRP1 genes[J].Tumour Biol,2016,37(12):16345-16355.
28 Peng WZ,Si S,Zhang QX,et al.Long non-coding RNA MEG3 functions as a competing endogenous RNA to regulate gastric cancer progression[J].J Exp Clin Cancer Res,2015,34(1):79.
29 Cai Q,Wang ZQ,Wang SH,et al.Upregulation of long non-coding RNA LINC00152 by SP1 contributes to gallbladder cancer cell growth and tumor metastasis via PI3K/AKT pathway[J].Am J Transl Res,2016,8(10):4068-4081.
30 Peng W,Wu G,Fan H,et al.Long noncoding RNA SPRY4-IT1 predicts poor patient prognosis and promotes tumorigenesis in gastric cancer[J].Tumour Biol,2015,36(9):6751-6758.
31 Liu L,Yan B,Yang Z,et al.ncRuPAR inhibits gastric cancer progression by down-regulating protease-activated receptor-1[J].Tumor Biol,2014,35(8):7821-7829.
32 Ma T,Wang RP,Zou X.Dioscin inhibits gastric tumor growth through regulating the expression level of LncRNA HOTAIR[J].BMC Complement Altern Med,2016,16(1):383.
33 Li H,Xie S,Liu X,et al.Matrine alters microRNA expression profiles in SGC-7901 human gastric cancer cells[J].Oncol Rep,2014,32(5):2118-2126.
34 Li KT,Duan QQ,Chen Q.The effect of aloe emodin-encapsulated nanoliposome-mediated r-caspase-3 gene transfection and photodynamic therapy on human gastric cancer cells[J].Cancer Med,2016,5(2):361-369.
35 Lei RR,Hu HF,Bai F,et al.Anti-proliferative and apoptotic effects of S1,a tetrandrine derivative,in human gastric cancer BGC-823 cells[J].Chin J Nat Med,2016,14(7):527-533.
36 Zheng LC,Yang MD,Kuo CL,et al.Norcantharidin-induced apoptosis of AGS human gastric cancer cells through reactive oxygen species production,and caspase-and mitochondria-dependent signaling pathways[J].Anticancer Res,2016,36(11):6031-6042.

[1]	秦文,赵楠楠,韩永焕,徐亚君. ZNF436在胃癌中的表达及调控WNT/β-catenin对胃癌细胞迁移及侵袭的影响[J]. 实用肿瘤学杂志, 2019, 33(3): 222-227.
[2]	孟海,杜观祥,朱利玲,汤琪云. WEE1在胃癌组织中的表达及对患者预后的影响[J]. 实用肿瘤学杂志, 2019, 33(3): 239-243.
[3]	刘佳音,燕飞虎,张艳桥. 凋亡基因Caspase3和Caspase7单核苷酸多态性与胃癌遗传易感性研究[J]. 实用肿瘤学杂志, 2019, 33(3): 250-255.
[4]	刘乙澍,曲国蕃. 长链非编码RNA在骨肉瘤中的研究进展[J]. 实用肿瘤学杂志, 2019, 33(3): 266-270.
[5]	白玉贤, 马仲娟, 苏颖玲, 慕安国, 谢蕊. 胃癌患者FHIT、hMLH1、p16、RAR-beta、Reprimo和TIMP3基因的甲基化研究[J]. 实用肿瘤学杂志, 2019, 33(1): 8-13.
[6]	张凤春, 江莺, 刘照南, 闫宁宁, 崔洪全, 徐迎春. 系统性炎症相关指标中性粒细胞/淋巴细胞比值及血小板/淋巴细胞比值在根治性切除术后的胃癌患者的预后意义[J]. 实用肿瘤学杂志, 2019, 33(1): 34-39.
[7]	张宝综述, 郑志超校审. 进展期胃癌淋巴结清扫研究进展[J]. 实用肿瘤学杂志, 2019, 33(1): 78-81.
[8]	唐淑丽, 何匡邦, 张纯慧, 程佳楠, 张艳桥. 胃癌组织中miR-320a和CYLD的表达及与临床病理特征及预后的关系[J]. 实用肿瘤学杂志, 2018, 32(6): 538-544.
[9]	伊庆亭, 张红军, 姜韬, 傅佳雷, 华明涛. 多烯磷脂酰胆碱在裸鼠模型中逆转胃癌细胞奥沙利铂耐药的作用及机制研究[J]. 实用肿瘤学杂志, 2018, 32(5): 385-390.
[10]	刘宏涛, 张彤彤综述, 刘雁军审校. 肥胖与结直肠癌发病机制的研究进展[J]. 实用肿瘤学杂志, 2018, 32(5): 464-467.
[11]	韩帮岭, 汪亦民综述, 薛英威审校. 维生素D在消化系统肿瘤中的研究进展[J]. 实用肿瘤学杂志, 2018, 32(5): 471-475.
[12]	徐文品, 焦琨(综述), 张伟(审校). 长链非编码RNAs在口腔鳞癌中的研究进展[J]. 实用肿瘤学杂志, 2018, 32(3): 258-262.
[13]	姚强, 王宽, 薛英威. SRC1在胃癌中的表达及其与预后的关系[J]. 实用肿瘤学杂志, 2018, 32(2): 97-102.
[14]	杨钊, 赵世光. 长链非编码RNA CASC2抑制肿瘤发生发展的研究概况[J]. 实用肿瘤学杂志, 2018, 32(2): 179-183.
[15]	张中民, 庞达. 长链非编码RNA调控癌症细胞信号通路的研究进展[J]. 实用肿瘤学杂志, 2018, 32(2): 184-188.

长链非编码RNA在胃癌中的调控机制及中药对其作用的研究概况

Regulative mechanism of long non-coding RNA in gastric cancer and its role in traditional Chinese medicine

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价