长链非编码RNA调控癌症细胞信号通路的研究进展

doi:10.11904/j.issn.1002-3070.2018.02.019

摘要/Abstract

摘要： 迄今为止,研究人员应用功能基因组学方法发现了多种类型的长链非编码RNA。长链非编码RNA能够调控基因的表达,并且在包括癌症等疾病发生发展过程中起着重要的作用。长链非编码RNA调控基因的表达过程有多种机制参与,例如对转录、翻译、蛋白质修饰及RNA-蛋白复合体形成或者蛋白-蛋白复合体形成等过程的调控。本文主要探讨长链非编码RNA调控肿瘤细胞信号通路的研究进展。

关键词: 长链非编码RNA, 癌症, 信号通路

Abstract: To date,various kinds of long non-coding RNAs(lncRNAs)have been found using functional genomics.LncRNAs can regulate gene expression,and play a significantly important role in the development of diseases including cancer.There are multiple mechanisms involved in the regulation of gene expression mediated by lncRNAs,such as the regulation of transcription,the process of translation,protein modification,and RNA-protein formation or protein-protein complex formation.In this review,we primarily discuss the latest research progress of the lncRNAs in the regulation of cancer cell signaling pathways.

Key words: Long non-coding RNAs(lncRNAs), Cancer, Singal pathways of cancer cells

中图分类号:

张中民, 庞达. 长链非编码RNA调控癌症细胞信号通路的研究进展[J]. 实用肿瘤学杂志, 2018, 32(2): 184-188.

ZHANG Zhongmin, PANG Da. Research progress of long non-coding RNA regulates cancer cell signaling pathways[J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(2): 184-188.

参考文献

1 Mercer TR,Dinger ME,Mattick JS.Long non-coding RNAs:insights into functions[J].Nat Rev Genet,2009,10(3):155-159.
2 Hangauer MJ,Vaughn IW,Mcmanus MT.Pervasive transcription of the human genome produces thousands of previously unidentified long intergenic noncoding RNAs[J].PLoS Genet,2013,9(6):e1003569.
3 Gibb EA,Brown CJ,Lam WL.The functional role of long non-coding RNA in human carcinomas[J].Mol Cancer,2011,10(1):38.
4 Esteller M.Non-coding RNAs in human disease[J].Nat Rev Genet,2011,12(12):861-874.
5 Wang Y,Chen L,Chen B,et al.Mammalian ncRNA-disease repository:a global view of ncRNA-mediated disease network[J].Cell Death Dis,2013,4(8):e765.
6 Wilusz JE.Long noncoding RNAs:Re-writing dogmas of RNA processing and stability[J].Biochim Biophys Acta,2016,1859(1):128-138.
7 Marques AC,Ponting CP.Intergenic lncRNAs and the evolution of gene expression[J].Curr Opin Genet Dev,2014,27(48):48-53.
8 Mattick JS,Rinn JL.Discovery and annotation of long noncoding RNAs[J].Nat Struct Mol Biol,2015,22(1):5-7.
9 Ulitsky I,Bartel DP.lincRNAs:genomics,evolution,and mechanisms[J].Cell,2013,154(1):26-46.
10 Jalali S,Jayaraj GG,Scaria V.Integrative transcriptome analysis suggest processing of a subset of long non-coding RNAs to small RNAs[J].Biol Direct,2012,7(1):1-13.
11 Kino T,Hurt DE,Ichijo T,et al.Noncoding RNA gas5 is a growth arrest and starvation-associated repressor of the glucocorticoid receptor[J].Sci Signal,2010,3(107):8.
12 Baldassarre A,Masotti A.Long non-coding RNAs and p53 regulation[J].Int J Mol Sci,2012,13(12):16708-16717.
13 Meller VH,Joshi SS,Deshpande N.Modulation of chromatin by noncoding RNA[J].Annu Rev Genet,2015,49(1):673-695.
14 Gupta RA,Shah N,Shah N,et al.Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis[J].Nature,2010,464(7291):1071-1076.
15 Tsai MC,Manor O,Wan Y,et al.Long noncoding RNA as modular scaffold of histone modification complexes[J].Science,2010,329(5992):689-693.
16 Huang J,Zhang A,Ho TT,et al.Linc-RoR promotes c-Myc expression through hnRNP I and AUF1[J].Nucleic Acids Res,2016,44(7):3059-3069.
17 Kashima T,Rao N,David CJ,et al.hnRNP A1 functions with specificity in repression of SMN2 exon 7 splicing[J].Hum Mol Genet,2007,16(24):3149-3159.
18 Tripathi V,Ellis JD,Shen Z,et al.The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation[J].Mol Cell,2010,39(6):925-938.
19 Yoon JH,Abdelmohsen K,Srikantan S,et al.LincRNA-p21 suppresses target mRNA translation[J].Mol Cell,2012,47(4):648-655.
20 Halaby MJ,Yang DQ.p53 translational control:a new facet of p53 regulation and its implication for tumorigenesis and cancer therapeutics[J].Gene,2007,395(1/2):1-7.
21 Grover R,Ray PS,Das S.Polypyrimidine tract binding protein regulates IRES-mediated translation of p53 isoforms[J].Cell Cycle,2008,7(14):2189-2198.
22 Zhang A,Zhou N,Huang J,et al.The human long non-coding RNA-RoR is a p53 repressor in response to DNA damage[J].Cell Res,2013,23(3):340-350.
23 Sullivan KD,Galbraith MD,Andrysik Z,et al.Mechanisms of transcriptional regulation in the p53 network[J].Cell Death Differ,2018,25(1):133-143.
24 Zhang A,Xu M,Mo YY.Role of the lncRNA-p53 regulatory network in cancer[J].J Mol Cell Biol,2014,6(3):181-191.
25 Schmitt AM,Garcia JT,Hung T,et al.An inducible long noncoding RNA amplifies DNA damage signaling[J].Nat Genet,2016,48(11):1370-1376.
26 Hung T,Wang Y,Lin MF,et al.Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters[J].Nat Genet,2011,43(7):621-629.
27 Liu Q,Huang J,Zhou N,et al.LncRNA loc285194 is a p53-regulated tumor suppressor[J].Nucleic Acids Res,2013,41(9):4976-4987.
28 Peppicelli S,Bianchini F,Contena C,et al.Acidic pH via NF-κB favours VEGF-C expression in human melanoma cells[J].Clin Exp Metastasis,2013,30(8):957-967.
29 Shi Q,Le X,Wang B,et al.Regulation of interleukin-8 expression by cellular pH in human pancreatic adenocarcinoma cells[J].J Interferon Cytokine Res,2000,20(11):1023-1028.
30 Xu L,Fidler IJ.Acidic pH-induced elevation in interleukin 8 expression by human ovarian carcinoma cells[J].Cancer Res,2000,60(16):4610-4616.
31 Lu T,Stark GR.NF-κB:regulation by methylation[J].Cancer Res,2015,75(18):3692-3695.
32 Aggarwal BB.Nuclear factor-κB:The enemy within[J].Cancer cell,2004,6(3):203-208.
33 Xu S,Ao J,Gu H,et al.IL-22 Impedes the proliferation of schwann cells:transcriptome sequencing and bioinformatics analysis[J].Mol Neurobiol,2016,54(4):2395-2405.
34 Krawczyk M,Emerson BM.p50-associated COX-2 extragenic RNA(PACER)activates COX-2 gene expression by occluding repressive NF-κB complexes[J].Elife,2014,3(3):e01776.
35 Liu B,Sun L,Liu Q et al.A cytoplasmic NF-κB interacting long noncoding RNA blocks IκB phosphorylation and suppresses breast cancer metastasis[J].Cancer Cell,2015,27(3):370-381.
36 Rapicavoli NA,Qu K,Zhang J,et al.A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics[J].Elife,2013,2(2):e00762.
37 Wu HW,Liu JF,Li W,et al.LncRNA-HOTAIR promotes TNF-alpha production in cardiomyocytes of LPS-induced sepsis mice by activating NF-kappa B pathway[J].Biochem Biophys Res Commun,2016,471(1):240-246.
38 Thorpe LM,Yuzugullu H,Zhao JJ.PI3K in cancer:divergent roles of isoforms,modes of activation and therapeutic targeting[J].Nat Rev Cancer,2015,15(1):7-24.
39 Michell BJ,Griffiths JE,Mitchelhill KI,et al.The Akt kinase signals directly to endothelial nitric oxide synthase[J].Curr Biol,1999,9(15):845-848.
40 Kim D,Kim S,Koh H,et al.Akt/PKB promotes cancer cell invasion via increased motility and metalloproteinase production[J].FASEB J,2001,15(11):1953-1962.
41 Koirala P,Huang J,Ho TT,et al.LncRNA AK023948 is a positive regulator of Akt[J].Nat Commun,2017,8:14422.
42 Qiao Q,Hong L.LncRNA FER1L4 suppresses cancer cell proliferation and cycle by regulating PTEN expression in endometrial carcinoma[J].Biochem Biophys Res Commun,2016,478(2):507-512.
43 Xu S,Sui S,Zhang J,et al.Downregulation of long noncoding RNA MALAT1 induces epithelial-to-mesenchymal transition via the PI3K-Akt pathway in breast cancer[J].Int J Clin Exp Pathol,2015,8(5):4881-4891.

[1]	刘乙澍,曲国蕃. 长链非编码RNA在骨肉瘤中的研究进展[J]. 实用肿瘤学杂志, 2019, 33(3): 266-270.
[2]	石小康, 丁佑铭, 汪斌, 余斌, 徐雨. UBE2T在原发性肝癌中的表达及临床意义[J]. 实用肿瘤学杂志, 2019, 33(2): 128-133.
[3]	刘恒辰, 张新宇. Toll样受体信号通路作为结直肠癌潜在治疗靶点的研究进展[J]. 实用肿瘤学杂志, 2019, 33(2): 188-192.
[4]	罗干, 易超, 依马木买买提江·阿布拉, 徐林, 尹继炜, 丁伟. Notch信号通路在胰腺癌中的表达及其作用研究[J]. 实用肿瘤学杂志, 2019, 33(1): 1-7.
[5]	丁界先, 张津, 陈永刚, 王兴文综述, 王栓科审校. Wnt信号通路与肿瘤发生的研究进展[J]. 实用肿瘤学杂志, 2019, 33(1): 73-77.
[6]	徐文品, 焦琨(综述), 张伟(审校). 长链非编码RNAs在口腔鳞癌中的研究进展[J]. 实用肿瘤学杂志, 2018, 32(3): 258-262.
[7]	马超(综述), 王国年(审校). 麻醉药物对围术期癌症患者免疫功能的影响[J]. 实用肿瘤学杂志, 2018, 32(3): 285-288.
[8]	杨钊, 赵世光. 长链非编码RNA CASC2抑制肿瘤发生发展的研究概况[J]. 实用肿瘤学杂志, 2018, 32(2): 179-183.
[9]	余嘉惠, 刘煊, 李琦, 陆烨, 岳小强. 长链非编码RNA在胃癌中的调控机制及中药对其作用的研究概况[J]. 实用肿瘤学杂志, 2018, 32(1): 47-52.
[10]	申美莹, 庞达. 长链非编码RNA在肿瘤微环境中的调控作用[J]. 实用肿瘤学杂志, 2018, 32(1): 73-76.
[11]	赵倩妤, 孙轶华. 拉曼光谱在癌症组织学诊断中的研究进展[J]. 实用肿瘤学杂志, 2018, 32(1): 92-96.
[12]	陈芊霖，庞达. 长链非编码RNA EPB41L4A-AS2对乳腺癌的预后研究[J]. 实用肿瘤学杂志, 2017, 31(3): 205-210.
[13]	顾秀瑛，顾晓芬，朱俊宇，周天虹，朱琳. 2014-2016年乌鲁木齐市9265例城市居民肺癌筛查结果分析[J]. 实用肿瘤学杂志, 2017, 31(3): 242-245.
[14]	于婧璐综述, 冯晓玲审校. 桦褐孔菌抗肿瘤机制的研究进展[J]. 实用肿瘤学杂志, 2017, 31(1): 69-72.
[15]	李根英，综述，张云艳，审校. MTBP与癌症的研究进展[J]. 实用肿瘤学杂志, 2016, 30(6): 560-562.