结肠癌中相关锌指蛋白的研究进展

doi:10.11904/j.issn.1002-3070.2018.06.017

摘要/Abstract

摘要： 结肠癌是全球常见的恶性肿瘤之一, 其发生发展机制复杂, 且尚未完全阐明。结肠癌的发病率与死亡率较高、预后差, 使人类健康受到严重威胁;锌指蛋白是一类具有锌指结构域的转录因子, 广泛参与人类体内的各种生物学活动, 尤其在调控基因表达方面意义显著。锌指蛋白因在结肠癌发生发展的分子调控过程中发挥重要作用, 并有望成为靶向治疗的新靶点而备受关注。本文就近年来锌指蛋白与结肠癌的相关研究进展做一综述。

关键词: 锌指蛋白, 结肠癌, 转录因子, 基因表达

Abstract: Colon cancer is one of the common malignant tumors in the world, and its mechanism of occurrence and development is complex and has not yet been fully elucidated.The incidence and mortality of colon cancer are high, and the prognosis is poor, which possess a serious threat to human health.Zinc finger protein is a kind of transcription factor with zinc finger domain, which is widely involved in various biological activities in humans, especially in notable regulating gene expression.Zinc finger protein plays an important role in the molecular regulation of colon cancer development and is expected to the development of colon cancer as a new target of targeted therapy.In this paper, the recent research progress of zinc finger protein and colon cancer is reviewed.

Key words: Zinc finger protein, Colon cancer, Transcription factor, Gene expression

中图分类号:

R735.3

艾廉杰综述, 朴大勋审校. 结肠癌中相关锌指蛋白的研究进展[J]. 实用肿瘤学杂志, 2018, 32(6): 567-570.

AI Lianjie, PIAO Daxun. Research progress in zinc finger proteins in colon cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(6): 567-570.

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