实用肿瘤学杂志 ›› 2019, Vol. 33 ›› Issue (1): 87-91.doi: 10.11904/j.issn.1002-3070.2019.01.016

• 综述 • 上一篇    下一篇

SNP对放射性肺损伤预测作用的研究进展

胡智慧 综述, 张静 审校   

  1. 石家庄市第一医院肿瘤一科(石家庄 050000)
  • 收稿日期:2018-07-03 出版日期:2019-02-28 发布日期:2019-02-13
  • 通讯作者: 胡智慧,E-mail:zhihui531@sina.com
  • 作者简介:胡智慧,女,(1984-),硕士,主治医师,从事肺癌放射性肺损伤的研究。

Research progress in the prediction of SNP on radiation-induced lung injury

HU Zhihui, ZHANG Jing   

  1. The First Hospital of Shijiazhuang,Shijiazhuang 050000,China
  • Received:2018-07-03 Online:2019-02-28 Published:2019-02-13

摘要: 放射治疗是肺癌重要的治疗方法,但其所致的放射性肺损伤(Radiation-induced lung injury,RILI)在对部分患者造成伤害的同时也影响了疗效。因此识别可能发生RILI的高风险患者从而采取措施干预或监测非常重要。尽管这种个体差异经常由临床和剂量学解释,但遗传因素也影响RILI的发生。目前对单核苷酸多态性(Single nucleotide polymorphism,SNP)与RILI的相关研究已有相关报道,这些特定基因的单核苷酸多态性或可成为RILI重要预测因素,进而减少放射性肺损伤的发生。

关键词: 放射性肺损伤, 单核苷酸多态性, 肺癌

Abstract: Radiotherapy is an important treatment for lung cancer.However,the radiation-induced lung injury(RILI)affects some patients and also affects the efficacy of treatment.Therefore,it is very important to identify high-risk patients who may have RILI and take action intervention or monitoring.Although the individual difference is often explained by clinical and dosimetric,genetic factors also influence the occurrence of RILI.Currently,there are reports on the relationship between single nucleotide polymorphism(SNP)and RILI.The SNP of these specific genes may become an important predictor of RILI,and thus reduce the incidence of radiation-induced lung injury.

Key words: Radiation-induced lung injury, Single nucleotide polymorphism, Lung cancer

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