SNP对放射性肺损伤预测作用的研究进展

doi:10.11904/j.issn.1002-3070.2019.01.016

摘要/Abstract

摘要： 放射治疗是肺癌重要的治疗方法,但其所致的放射性肺损伤(Radiation-induced lung injury,RILI)在对部分患者造成伤害的同时也影响了疗效。因此识别可能发生RILI的高风险患者从而采取措施干预或监测非常重要。尽管这种个体差异经常由临床和剂量学解释,但遗传因素也影响RILI的发生。目前对单核苷酸多态性(Single nucleotide polymorphism,SNP)与RILI的相关研究已有相关报道,这些特定基因的单核苷酸多态性或可成为RILI重要预测因素,进而减少放射性肺损伤的发生。

关键词: 放射性肺损伤, 单核苷酸多态性, 肺癌

Abstract: Radiotherapy is an important treatment for lung cancer.However,the radiation-induced lung injury(RILI)affects some patients and also affects the efficacy of treatment.Therefore,it is very important to identify high-risk patients who may have RILI and take action intervention or monitoring.Although the individual difference is often explained by clinical and dosimetric,genetic factors also influence the occurrence of RILI.Currently,there are reports on the relationship between single nucleotide polymorphism(SNP)and RILI.The SNP of these specific genes may become an important predictor of RILI,and thus reduce the incidence of radiation-induced lung injury.

Key words: Radiation-induced lung injury, Single nucleotide polymorphism, Lung cancer

中图分类号:

R734.2

胡智慧综述, 张静审校. SNP对放射性肺损伤预测作用的研究进展[J]. 实用肿瘤学杂志, 2019, 33(1): 87-91.

HU Zhihui, ZHANG Jing. Research progress in the prediction of SNP on radiation-induced lung injury[J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(1): 87-91.

参考文献

1 Cannon DM,Mehta MP,Adkison JB,et al.Dose-limiting toxicity after hypofractionated dose-escalated radiotherapy in non-small-cell lung cancer[J].Clin Oncol,2013,31(34):4343-4348.
2 Farr KP,Kallehauge JF,Moller DS,et al.Inclusion of functional information from perfusion SPECT improves predictive value of dose-volume parameters in lung toxicity outcome after radiotherapyfor non-small cell lung cancer:A prospective study[J].Radiother Oncol,2015,117(1):9-16.
3 Zhang XJ,Sun JG,Sun J,et al.Prediction of radiation pneumonitis in lung cancer patients:A systematic review[J].Cancer Res Clin Oncol,2012,138(12):2103-2116.
4 Giuliani ME,Lindsay PE,Kwan JY,et al.Correlation of dosimetric and clinical factors with the development of esophagitis and radiation pneumonitis in patients with limited-stage small-cell lung carcinoma[J].Clin Lung Cancer,2015,16(3):216-220.
5 Dang J,Li G,Zang S,et al.Comparison of risk and predictors for early radiation pneumonitis in patients with locally advanced non-small cell lung cancer treated with radiotherapy with or without surgery[J].Lung Cancer,2014,86(3):329-333.
6 Tsujino K,Hashimoto T,Shimada T,et al.Combined analysis of V20,VS5,pulmonary fibrosis score on baseline computed tomography and patient age improves prediction of severe radiation pneumonitis after concurrent chemoradiotherapy for locally advanced non-small-cell lung cancer[J].Thorac Oncol,2014,9(7):983-990.
7 Dang J,Li G,Zang S,et al.Risk and predictors for early radiation pneumonitis in patients with stage III non-small cell lung cancer treated with concurrent or sequential chemoradiotherapy[J].Radiat Oncol,2014,9(1):172.
8 Schallenkamp JM,Miller RC,Brinkmann DH,et al.Incidence of radiation pneumonitis after thoracic irradiation:Dose-volume correlates[J].Int J Radiat Oncol Biol Phys,2007,67(2):410-416.
9 Tang C,Gomez DR,Wang H,et al.Association between white blood cell count following radiation therapy with radiation pneumonitis in non-small cell lung cancer[J].Int J Radiat Oncol Biol Phys,2014,88(2):319-325.
10 Barnett GC,Elliott RM,Alsner J,et al.Individual patient data meta-analysis shows no association between the SNP rs1800469 in TGFB and late radiotherapy toxicity[J].Radiother Oncol,2012,105(3):289.
11 Yuan X,Liao Z,Liu Z,et al.Single nucleotide polymorphism at rs1982073:T869C of the TGF beta 1 gene is associated with the risk of radiation pneumonitis in patients with non-small-cell lung cancer treated with definitive radiotherapy[J].Clin Oncol,2009,27(20):3370-3378.
12 Shen ZT,Shen JS,Ji XQ,et al.TGF-β1 rs1982073 polymorphism contributes to radiation pneumonitis in lung cancer patients:A meta-analysis[J].Cell Mol Med,2016,20(12):2405-2409.
13 Niu X,Li H,Chen Z,et al.A study of ethnic differences in TGF-β1gene polymorphisms and effects on the risk of radiation pneumonitis in non-small-cell lung cancer[J].Thorac Oncol,2012,7(11):1668-1675.
14 Roos WP,Thomas AD,Kaina B.DNA damage and the balance between survival and death in cancer biology[J].Nat Rev Cancer,2016,16(1):20-33.
15 Kelsey CR,Jackson IL,Langdon S,et al.Analysis of single nucleotide polymorphisms and radiation sensitivity of the lung assessed with an objective radiologic endpoint[J].Clin Lung Cancer,2013,14(3):267-274.
16 Yin M,Liao Z,Liu Z,et al.Functional polymorphisms of base excision repair genes XRCC1 and APEX1 predict risk of radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy[J].Int J Radiat Oncol Biol Phys,2011,81(3):67-73.
17 Yin M,Liao Z,Huang YJ,et al.Polymorphisms of homologous recombination genes and clinical outcomes of non-small cell lung cancer patients treated with definitive radiotherapy[J].PLoS One,2011,6(5):e20055.
18 Tucker SL,Li M,Xu T,et al.Incorporating single-nuleotide polymorphisms into the Lyman model to improve prediction of radiation pneumonitis[J].Int J Radiat Oncol Biol Phys,2013,85(1):251-257.
19 Yin M,Liao Z,Liu Z,et al.Genetic variants of the nonhomologous end joining gene LIG4 and severe radiation pneumonitis in non-small cell lung cancer patients treated with definitive radiotherapy[J].Cancer,2012,118(2):528-535.
20 Li H,Liu G,Xia L,et al.A polymorphism in the DNA repair domain of APEX1 is associated with the radiation-induced pneumonitis risk among lung cancer patients after radiotherapy[J].Br J Radiol,2014,87(1040):20140093.
21 Liu H,Colavitti R,RoviraII,et al.Redox-dependent transcriptional regulation[J].Circ Res,2005,97(10):967-974.
22 Tell G,Fantini D,Quadrifoglio F.Understanding different functions of mammalian AP endonuclease(APE1)as a promising tool for cancer treatment[J].Cell Mol Life Sci,2010,67(21):3589-3608.
23 Nakamura T,Ito T,Igarashi H,et al.Cytosolic double-stranded DNA as a damage-associated molecular pattern induces the inflammatory response in rat pancreatic stellate cells:a plausible mechanism for tissue injury-associated pancreatitis[J].Int J Inflam,2012,2012(12):504128.
24 Stankovic T,Stewart GS,Byrd P,et al.ATM mutations in sporadic lymphoid tumours[J].Leuk Lymphoma,2002,43(8):1563-1571.
25 Yang M,Zhang L,Bi N,et al.Association of P53 and ATM polymorphisms with risk of radiation-induced pneumonitis in lung cancer patients treated with radiotherapy[J].Int J Radiat Oncol Biol Phys,2011,79(5):1402-1407.
26 Liu J,Wang X,Ren Y,et al.Effect of single nucleotide polymorphism rs189037 in ATM gene on risk of lung cancer in Chinese:A case-control study[J].PLoS One,2014,9(12):e115845.
27 Xiong H,Liao Z,Liu Z,et al.ATM polymorphisms predict severe radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy[J].Int J Radiat Oncol Biol Phys,2013,85(4):1066-1073.
28 Zhang L,Yang M,Bi N,et al.ATM polymorphisms are associated with risk of radiation-induced pneumonitis[J].Int J Radiat Oncol Biol Phys,2010,77(5):1360-1368.
29 Du L,Yu W,Dai X,et al.Association of DNA repair gene polymorphisms with the risk of radiation pneumonitis in lung cancer patients[J].Oncotarget,2018,9(1):958-968.
30 Chang Claude J,Popanda O,Tan XL,et al.Association between polymorphisms in the DNA repair genes,XRCC1,APE1,and XPD and acute side effects of radiotherapy in breast cancer patients[J].Clin Cancer Res,2005,11(13):4802-4809.
31 RzeszowskaWolny J,Polanska J,Pietrowska M,et al.Influence of polymorphisms in DNA repair genes XPD,XRCC1 and MGMT on DNA damage induced by gamma radiation and its repair in lymphocytes in vitro[J].Radiat Res,2005,164(2):132-140.
32 Zhang L,Yang M,Bi N,et al.Association of TGF-β1 and XPD polymorphisms with severe acute radiation-induced esophageal toxicity in locally advanced lung cancer patients treated with radiotherapy[J].Radiother Oncol,2010,97(1):19-25.
33 Zhang Y,Luo Z,Yang L,et al.The association between four SNPs of X-ray repair cross complementing protein 1 and the sensitivity to radiotherapy in patients with esophageal squamous cell carcinoma[J].Oncol Lett,2016,11(5):3508-3514.
34 Mak RH,Alexander BM,Asomaning K,et al.A single nucleotide polymorphism in the MTHFR gene is associated with risk of radiation pneumonitis in lung cancer patients treated with thoracic radiation therapy[J].Cancer,2012,118(14):3654-3665.
35 Mymrikov EV,Seitnebi AS,Gusev NB.Large potentials of small heat shock proteins[J].Physiol Rev,2011,91(4):1123-1159.
36 Laskowska E.Small heat shock proteins-role in apoptosis,cancerogenesis and diseases associated with protein aggregation[J].Postepy Biochem,2007,53(1):19-26.
37 Schmid TE,Multhoff G.Radiation-induced stress proteins-the role of heat shock proteins(HSP)in anti-tumor responses[J].Curr Med Chem,2012,19(12):1765-1770.
38 Arrigo AP,Virot S,Chaufour S,et al.Hsp27 consolidates intracellular redox homeostasis by upholding glutathione in its reduced form and by decreasing iron intracellular levels[J].Antioxid Redox Signal,2005,36(39):414-422.
39 Pang Q,Wei Q,Xu T,et al.Functional promoter variant rs2868371 of HSPB1 is associated with risk of radiation pneumonitis after chemoradiation for non-small cell lung cancer[J].Int J Radiat Oncol Biol Phys,2013,85(5):1332-1339.
40 Medinger M,Passweg J.Angiogenesis in myeloproliferative neoplasms,new markers and future directions[J].Memo,2014,7(4):206-210.
41 Mittal K,Ebos J,Rini B.Angiogenesis and the tumor microenvironment:Vascular endothelial growth factor and beyond[J].Semin Oncol,2014,41(2):235-251.
42 Folkman J.Role of angiogenesis in tumor growth and metastasis[J].Semin Oncol,2002,29(6):15-18.
43 Lum H,Roebuck KA.Oxidant stress and endothelial cell dysfunction[J].Am J Physiol Cell Physiol,2001,280(4):719-741.
44 Fisher M.Injuries to the vascular endothelium:Vascular wall and endothelial dysfunction[J].Rev Neurol Dis,2008,5(1):4-11.
45 Anbalagan D,Yap G,Yuan Y,et al.Annexin-A1 regulates microRNA-26b* and microRNA-562 to directly target NF-κB and angiogenesis in breast cancer cells[J].PLoS One,2014,9(9):e114507.
46 Yin M,Liao Z,Yuan X,et al.Polymorphisms of the vascular endothelial growth factor gene and severe radiation pneumonitis in non-small cell lung cancer patients treated with definitive radiotherapy[J].Cancer Sci,2012,103(5):945-950.

[1]	张佳文,于雁,张薇,曹京燕,罗雯,尚利华. 基于UPLC-TOF/MS的小细胞肺癌患者血清代谢组学研究[J]. 实用肿瘤学杂志, 2019, 33(3): 200-205.
[2]	孙立春,李丹丹,李净,于凤玲. CCDC8和TGF-β1在非小细胞肺癌中的表达及临床意义[J]. 实用肿瘤学杂志, 2019, 33(3): 215-221.
[3]	刘志强,褚艳杰,刘静,王彦博. m白术内酯Ⅰ通过TLR4/MyD88通路调控肺癌A549细胞增殖侵袭的研究[J]. 实用肿瘤学杂志, 2019, 33(3): 228-232.
[4]	刘佳音,燕飞虎,张艳桥. 凋亡基因Caspase3和Caspase7单核苷酸多态性与胃癌遗传易感性研究[J]. 实用肿瘤学杂志, 2019, 33(3): 250-255.
[5]	张彦秋,韩阿蒙,李金旺,顾涛,付占昭,毛羽,张子健,杨振. CRT+ARC技术在局部晚期肺癌患者中临床应用的初步研究[J]. 实用肿瘤学杂志, 2019, 33(3): 256-260.
[6]	赵苏, 郑晓瑜, 朱开彬, 卜建龙, 徐世东. 肺癌完全性切除术对患者外周血中Th17/Treg细胞平衡的影响[J]. 实用肿瘤学杂志, 2019, 33(2): 142-148.
[7]	迪娜·木拉力, 胡昕综述, 加孜那·托哈依审校. 远程医疗在肺癌中的应用及前景[J]. 实用肿瘤学杂志, 2018, 32(6): 555-557.
[8]	李万祯, 殷俊, 李萍, 林晓辉, 张国前, 张书旭. iR-17在非小细胞肺癌放射抗拒细胞中的表达及作用研究[J]. 实用肿瘤学杂志, 2018, 32(5): 391-397.
[9]	蔡静, 候玥. 非小细胞肺癌患者血清miR-195的表达及其临床意义[J]. 实用肿瘤学杂志, 2018, 32(5): 415-419.
[10]	钟雪莱, 杨海粒, 王国年. 不同麻醉方式对老年肺癌患者术后认知功能的影响[J]. 实用肿瘤学杂志, 2018, 32(5): 432-436.
[11]	朱晓云, 张亚宁, 林菲, 马碧萍. 上海市金山区2002-2013年肺癌发病及死亡分析[J]. 实用肿瘤学杂志, 2018, 32(5): 437-441.
[12]	崔晓燕, 涂青, 甘建辉. 纳布啡与羟考酮自控镇痛对非小细胞肺癌患者术后免疫因子水平影响的比较[J]. 实用肿瘤学杂志, 2018, 32(4): 309-314.
[13]	魏静, 陶媛美慧, 付英梅, 赵吉子, 张文莉, 张凤民. 肺结核与肺癌相互影响的研究进展[J]. 实用肿瘤学杂志, 2018, 32(4): 340-343.
[14]	雷俊华, 许冠华, 曾江正, 黄芬, 何志惠, 卢彦达. 隐丹参酮联合顺铂抗非小细胞肺癌NCI-H1975细胞JAK2/STAT3机制研究[J]. 实用肿瘤学杂志, 2018, 32(3): 198-202.
[15]	万静萱, 李红红, 周湘乡, 马琳. Ⅳ期肺癌合并肺血栓栓塞的危险因素分析[J]. 实用肿瘤学杂志, 2018, 32(3): 214-244.