实用肿瘤学杂志 ›› 2019, Vol. 33 ›› Issue (2): 188-192.doi: 10.11904/j.issn.1002-3070.2019.02.017

• 综述 • 上一篇    

Toll样受体信号通路作为结直肠癌潜在治疗靶点的研究进展

刘恒辰(综述), 张新宇(审校)   

  1. 哈尔滨医科大学附属第二医院(哈尔滨 150001)
  • 收稿日期:2018-08-27 修回日期:2018-12-03 出版日期:2019-04-20 发布日期:2019-04-25
  • 通讯作者: 张新宇,E-mail:xinyuzhang3052000@yahoo.com.cn
  • 作者简介:刘恒辰,男,(1993-),硕士,住院医师,从事腹腔镜微创的研究

Toll-like receptor signaling pathway as a potential therapeutic target for colorectal cancer

LIU Hengchen, ZHANG Xinyu   

  1. The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China
  • Received:2018-08-27 Revised:2018-12-03 Online:2019-04-20 Published:2019-04-25

摘要:

Toll样受体(Toll-like receptors,TLRs)信号通路参与激活固有免疫和适应性免疫应答,在结直肠癌的发生发展中发挥重要作用。TLRs信号通路失调可导致上皮出血、慢性炎症以及促进结直肠癌的发展。现在有大量证据表明靶向这一途径将有益于结直肠癌的治疗,如卡介苗、单磷酰脂A、咪喹莫特等现已应用于临床。本文综述了目前有关TLRs在肿瘤发展中的不同功能及其在结直肠癌治疗中的应用。

关键词: 结直肠癌, 免疫反应, Toll样受体信号通路

Abstract:

Toll-like receptors(TLRs)signaling pathways are involved in the activation of innate and adaptive immune response and play an important role in the development of colorectal cancer.Deregulation of TLRs signaling pathway can lead to epithelial hemorrhage,chronic inflammation and the development of colorectal cancer.There is now lots of evidence that targeting this pathway will benefit the treatment of colorectal cancer,such as BCG,monophosphatidyl A,and iquimod,etc.,which are now in clinical use.This article reviews current different function of TLRs in tumor development and their application in the treatment of colorectal cancer.

Key words: Colorectal cancer, Immune response, Toll-like receptor signaling pathway

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