CCDC8和TGF-β1在非小细胞肺癌中的表达及临床意义

doi:10.11904/j.issn.1002-3070.2019.03.005

实用肿瘤学杂志 ›› 2019, Vol. 33 ›› Issue (3): 215-221.doi: 10.11904/j.issn.1002-3070.2019.03.005

CCDC8和TGF-β1在非小细胞肺癌中的表达及临床意义

孙立春¹,李丹丹¹,李净²,于凤玲³

1.哈尔滨医科大学附属肿瘤医院(哈尔滨 150081);
2.哈尔滨市胸科医院;
3.黑龙江省农垦总院

收稿日期:2019-01-24 修回日期:2019-05-05 出版日期:2019-06-20 发布日期:2019-06-18
通讯作者: 孙立春,E-mail:sunlichun114@163.com
作者简介:孙立春,女,(1969-),博士,副主任医师,从事肿瘤临床及耐药的研究
基金资助:
黑龙江省教育厅科研资助项目(编号:12541457)

Expression and clinical significance of CCDC8 and TGF-β1 in non-small cell lung cancer

SUN Lichun¹,LI Dandan¹,LI Jing²,YU Fengling³

1.Harbin Medical University Cancer Hospital,Harbin 150081,China;
2.Harbin Chest Hospital;
3.Heilongjiang Provincial Agricultural Reclamation General Hospital

Received:2019-01-24 Revised:2019-05-05 Online:2019-06-20 Published:2019-06-18

摘要/Abstract

摘要： 目的探讨CCDC8和TGF-β1在非小细胞肺癌中的表达及其与临床病理特征的关系。方法比较TCGA数据库正常肺组织与肿瘤组织中CCDC8和TGF-β1的表达量,分析非小细胞肺癌中CCDC8和TGF-β1表达的相关性。免疫组织化学染色检测204例常规石蜡包埋非小细胞肺癌组织CCDC8、TGF-β1表达并分析其与肺癌临床病理特征关系。利用Kaplan-Meier法绘制生存曲线,应用Cox回归分析CCDC8、TGF-β1表达与患者总生存期(OS)的关系。结果 TCGA数据中正常肺组织CCDC8与TGF-β1表达较肿瘤组织中高(P＜0.05),非小细胞肺癌患者CCDC8表达与TGF-β1表达呈正相关(P＜0.0001);鳞癌中CCDC8低表达患者OS长(HR=1.32,P=0.0437)。204例非小细胞肺癌组织中,CCDC8表达与TGF-β1表达呈正相关(P=0.023)。Cox单因素分析鳞癌中CCDC8表达与OS有关(P=0.013);而CCDC8和TGF-β1表达与腺癌患者生存无关(P=0.967,P=0.816)。Cox多因素分析TNM分期、CCDC8表达是肺鳞癌患者预后因子(P=0.016)。结论非小细胞肺癌中CCDC8表达与TGF-β1表达正相关,CCDC8可能是肺鳞癌患者预后因子。

关键词: 卷曲螺旋结构蛋白8, 转化生长因子β1, 非小细胞肺癌

Abstract: Objective The aim of this study was to investigate the expression of CCDC8(coiled-coil domain containing 8,P90)and transforming growth factor β 1(TGF- β1)in none small cell lung cancer(NSCLC),and its relationship with clinicopathological characteristics.Methods The expression of CCDC8 and TGF-β1 in NSCLC was analyzed in the TCGA database.The Kaplan-Meier curve was plotted to analyze its correlation with survival of patient.The expression of CCDC8 and TGF-β1 in 204 cases of conventional paraffin-embedded NSCLC was detected by immunohistochemical staining and their relationship with clinicopathological features of NSCLC was analyzed.The relationship between the expression of CCDC8 and TGF-β1 and the overall survival(OS)of patients was analyzed by Cox regression.Results The expression of CCDC8 in NSCLC patients was positively correlated with TGF-β1 expression in the TCGA data(P＜0.05).OS was low in patients with the low expression of CCDC8(HR=1.32,P=0.0437).In 204 NSCLC tissues,CCDC8 expression was positively correlated with TGF-β1 expression(P=0.023).Cox univariate analysis of CCDC8 expression in NSCLC was associated with OS(P=0.013);whereas the expression of CCDC8 and TGF-β1 was not associated with survival in patients with NSCLC(P=0.967,P=0.816).Cox multivariate analyses of TNM staging and CCDC8 were prognosis factors in patients with NSCLC(P=0.016).Conclusion The expression of CCDC8 is correlated the expression of TGF-β1 in NSCLC.CCDC8 may be a prognostic factor for patients with NSCLC.

Key words: CCDC8, TGF-β1, NSCLC

中图分类号:

R734.2

孙立春,李丹丹,李净,于凤玲. CCDC8和TGF-β1在非小细胞肺癌中的表达及临床意义[J]. 实用肿瘤学杂志, 2019, 33(3): 215-221.

SUN Lichun,LI Dandan,LI Jing,YU Fengling. Expression and clinical significance of CCDC8 and TGF-β1 in non-small cell lung cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(3): 215-221.

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CCDC8和TGF-β1在非小细胞肺癌中的表达及临床意义

Expression and clinical significance of CCDC8 and TGF-β1 in non-small cell lung cancer

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