Wnt7a与恶性肿瘤的关系及研究进展

doi:10.11904/j.issn.1002-3070.2019.03.015

摘要/Abstract

摘要： Wnt7a是Wnt信号家族成员中的一种分泌糖蛋白,位于染色体3p25上,极易缺失,主要在胎盘、肾脏、睾丸、子宫、胎肺及人脑中表达,参与人体的胚胎发育及细胞分化。越来越多的研究发现,Wnt7a在很多肿瘤细胞中也有表达,并起着举足轻重的作用。作为一个新的肿瘤治疗靶点或者肿瘤生长通路中重要的因子,Wnt7a开始受到越来越多科学家的注意。

关键词: Wnt7a, 肿瘤, 过表达, 治疗靶点

Abstract: Wnt7a is a secreted glycoprotein in the Wnt signaling family.It is located on chromosome 3p25 and is easy deleted.It is mainly expressed in placenta,kidney,testis,uterus,fetal lung and brain,and participates in human embryonic development and cell differentiation.More and more studies have found that Wnt7a is also expressed and plays an important role in many tumor cells.As a new tumor target of therapy or an important factor in the tumor growth pathway,Wnt7a has begun to attract the attention of many scientists.

Key words: Wnt7a, Tumor, Overexpression, Therapeutic target

中图分类号:

侯玉雪,李晓莉. Wnt7a与恶性肿瘤的关系及研究进展[J]. 实用肿瘤学杂志, 2019, 33(3): 271-275.

HOU Yuxue,LI Xiaoli. The research progress of Wnt7a and malignant tumors,and its relationship[J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(3): 271-275.

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