长链非编码RNA CCAT1与消化系统恶性肿瘤关系的研究进展

doi:10.11904/j.issn.1002-3070.2019.04.015

摘要/Abstract

摘要： 长链非编码RNA(Long non-coding RNA,Lnc RNA)是序列长度大于200个核苷酸且不翻译成蛋白质的功能性RNA分子。LncRNA在恶性肿瘤的临床应用中有重大价值,与肿瘤的诊断、预防、治疗及预后有密切联系。人类结肠癌相关转移因子-1(Colon cancer associated transcript-1 CCAT1)可以通过促进细胞增殖、侵袭和迁移来发挥致癌作用,CCAT1可以作为肿瘤预后的生物标志物。本文就近年来人们对于CCAT1与消化系统恶性肿瘤关系的研究进展做一综述,并探讨通过CCAT1治疗恶性肿瘤的现状和前景。

Abstract: Long non-coding RNAs(lncRNAs)is a functional RNA molecule with a sequence length greater than 200 nucleotides that is not translated into a protein.LncRNA is of great value in the clinical application of malignant tumors and is closely related to the diagnosis,prevention,treatment and prognosis of tumors.CCAT1(human colon cancer associated transcript-1)can play a carcinogenic role by promoting cell proliferation,invasion and migration.CCAT1 can be used as a biomarker for tumor prognosis.In this review,the research progress on the relationship between CCAT1 and digestive system malignant tumors is reviewed in recent years,the current status and prospects of malignant tumor treatment by CCAT1 are discussed.

Key words: CCAT1, Long noncoding RNA, Digestive system cancer, Cancer biomarker

中图分类号:

R735

赵金璐, 李国东刘明. 长链非编码RNA CCAT1与消化系统恶性肿瘤关系的研究进展[J]. 实用肿瘤学杂志, 2019, 33(4): 367-370.

ZHAO Jinlu, LI Guodong, LIU Ming. Advanced in the relation between long-chain non-coding RNA CCAT1 and digestive system malignancies[J]. Journal of Practical Oncology, 2019, 33(4): 367-370.

参考文献

1 Ferlay J,Soerjomataram I,Dikshit R,et al.Cancer incidence and mortality worldwide:sources,methods and major patterns in GLOBOCAN 2012[J].Int J Cancer,2015,136(5):359-386.
2 Roberts TC,Morris KV,Weinberg MS.Perspectives on the mechanism of transcriptional regulation by long non-coding RNAs[J].Epigenetics,2014,9(1):13-20.
3 Spizzo R,Almeida MI,Colombatti A,et al.Long non-coding RNAs and cancer:a new frontier of translational research?[J].Oncogene,2012,31(43):4577-4587.
4 Yang F,Zhang L,Huo XS,et al.Long noncoding RNA high expression in hepatocellular carcinoma facilitates tumor growth through enhancer of zeste homolog 2 in humans[J].Hepatology,2011,54(5):1679-1689.
5 Nissan A,Stojadinovic A,Mitrani-Rosenbaum S,et al.Colon cancer associated transcript-1:a novel RNA expressed in malignant and premalignant human tissues[J].Int J Cancer,2012,130(7):1598-1606.
6 Zhang XF,Liu T,Li Y,et al.Overexpression of long non-coding RNA CCAT1 is a novel biomarker of poor prognosis in patients with breast cancer[J].Int J Clin Exp Pathol,2015,8(8):9440-9445.
7 White NM,Cabanski CR,Silva-Fisher JM,et al.Transcriptome sequencing reveals altered long intergenic non-coding RNAs in lung cancer[J].Genome Biol,2014,15(8):429.
8 Cabnaski CR,White NM,Dang HX,et al.Pan-cancer transcriptome analysis reveals long noncoding RNAs with conserved function[J].RNA Biol,2015,12(6):628-642.
9 Chen L,Wang W,Cao L,et al.Long non-coding RNA CCAT1 acts as a competing endogenous RNA to regulate cell growth and differentiation in acute myeloid leukemia[J].Mol Cells,2016,39(4):330-336.
10 Alaiyan B,Ilyayev N,Stojadinovic A,et al.Differential expression of colon cancer associated transcript l(CCAT1)along the colonic denoma-carcinoma sequence[J].BMC Cancer,2013,13:196.
11 Karn Y,Rubinstein A,Naik S,et al.Detection of a long non-coding RNA(CCAT1)in living cells and human adenocarcinoma of colon tissues using FIT-PNA molecular beacons[J].Cancer Lett,2014,352(1):90-96.
12 Zhao W,Song M,Zhang J,et al.Combined identification of long non-coding RNA CCAT1 and HOTAIR in serum as an effective screening for colorectal carcinoma[J].Int J Clin Exp Pathol,2015,8(11):14131-14140.
13 Cui G,Zhang T,Cui J.Value of colon cancer associated transcription factor 1 expression in early screening and prognosis assessment for patients with colorectal carcinoma[J].J Nanjing Med Univ,2015,35(7):1008-1012.
14 He X,Tan X,Wang X,et al.C-Myc-activated long noncoding RNA CCAT1 promotes colon cancer cell proliferation and invasion[J].Tumour Biol,2014,35(12):12181-12188.
15 Xiang JF,Yin QF,Chen T,et al.Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus[J].Cell Res,2014,24(5):513-531.
16 Ye Z,Zhou M,Tian B,et al.Expression of lncRNA CCAT1,E-cadherin and N-cadherin in colorectal cancer and its cilinical significane[J].Int J Clin Exp Med,2015,8(3):3730-3715.
17 Yang F,Xue X,Bi J,et al.Long noncoding RNA CCAT1,which could be activated by c-Myc,promotes the progression of gastric carcinoma[J].J Cancer Res Clin Oncol,2013,139(3):437-445.
18 Mizrahi I,Mazeh H,Grinbaum R,et al.Colon cancer associated transcript-1(CCAT1)expression in adenocarcinoma of the stomach[J].J Cancer,2015,6(2):105-110.
19 Fang H,Liu HM,Wu WH,et al.Upregulation of long noncoding RNA CCAT1-L promotes epithelial-mesenchymal transition in gastric adenocarcinoma[J].Onco Targets Ther,2018,11:5647-5655.
20 Zhou B,Wang Y,Jiang J,et al.The long noncoding RNA colon cancer-associated transcript-1/miR-490 axis regulates gastric cancer cell migration by targeting hnRNPA1[J].IUBMB Life,2016,68(3):201-210.
21 Zhu HQ,Zhou X,Chang H,et al.CCAT1 promotes hepatocellular carcinoma cell prolifer-ation and invasion[J].Int J Clin Exp Pathol,2015,8(5):5427-5434.
22 Deng L,Yang SB,Xu FF,et al.Long noncoding RNA CCAT1 promotes hepatocellular carcinoma progression by functioning as let-7 sponge[J].J Exp Clin Cancer Res,2015,34(1):18.
23 Yu QY,Zhou XF,Xia Q,et al.Long non-coding RNA CCAT1 that can be activated by c-Myc promotes pancreatic cancer cell proliferation and migration[J].Am J Transl Res,2016,8(12):5444-5454.
24 Zhang E,Han L,Yin D,et al.H3K27 acetylation activated-long non-coding RNA CCAT1 affects cell proliferation and migration by regulating SPRY4 and HOXB13 expression in esophageal squamous cell carcinoma[J].Nucleic Acids Res,2017,45(6):3086-3101.
25 Jiang Y,Jiang YY,Xie JJ,et al.Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression[J].Nat Commun,2018,9(1):3619.
26 Ma MZ,Chu BF,Zhang Y,et al.Long non-coding RNA CCAT1 promotes gallbladder cancer development via negative modulation of miRNA-218-5p[J].Cell Death Dis,2015,6:e1583.
27 Jiang XM,Li ZL,Li JL,et al.LncRNA CCAT1 as the unfavorable prognostic biomarker for cholangiocarcinoma[J].Eur Rev Med Pharmacol Sci,2017,21(6):1242-1247.
28 Zhang S,Xiao J,Chai Y,et al.LncRNA-CCAT1 promotes migration,invasion,and EMT in intrahepatic cholangiocarcinoma through suppressing miR-152[J].Dig Dis Sci,2017,62(11):3050-3058.
29 张中民,庞达.长链非编码RNA调控癌症细胞信号通路的研究进展[J].实用肿瘤学杂志,2018,32(2):184-188.

[1]	刘乙澍,曲国蕃. 长链非编码RNA在骨肉瘤中的研究进展[J]. 实用肿瘤学杂志, 2019, 33(3): 266-270.
[2]	徐文品, 焦琨(综述), 张伟(审校). 长链非编码RNAs在口腔鳞癌中的研究进展[J]. 实用肿瘤学杂志, 2018, 32(3): 258-262.
[3]	张中民, 庞达. 长链非编码RNA调控癌症细胞信号通路的研究进展[J]. 实用肿瘤学杂志, 2018, 32(2): 184-188.
[4]	杨钊, 赵世光. 长链非编码RNA CASC2抑制肿瘤发生发展的研究概况[J]. 实用肿瘤学杂志, 2018, 32(2): 179-183.
[5]	申美莹, 庞达. 长链非编码RNA在肿瘤微环境中的调控作用[J]. 实用肿瘤学杂志, 2018, 32(1): 73-76.
[6]	余嘉惠, 刘煊, 李琦, 陆烨, 岳小强. 长链非编码RNA在胃癌中的调控机制及中药对其作用的研究概况[J]. 实用肿瘤学杂志, 2018, 32(1): 47-52.
[7]	陈芊霖，庞达. 长链非编码RNA EPB41L4A-AS2对乳腺癌的预后研究[J]. 实用肿瘤学杂志, 2017, 31(3): 205-210.
[8]	王鹏综述, 王征, 周志祥审校. p53与消化系统恶性肿瘤的研究进展[J]. 实用肿瘤学杂志, 2016, 30(5): 468-472.
[9]	池淑琦综述, 汪宏波审校. 长链非编码RNA与肿瘤耐药性的研究进展[J]. 实用肿瘤学杂志, 2016, 30(2): 150-153.
[10]	邵晓琳综述, 张韬审校. 头颈部肿瘤相关长链非编码RNA的研究进展[J]. 实用肿瘤学杂志, 2016, 30(1): 88-92.
[11]	周婧, 综述, 李志高审校. Girdin蛋白与乳腺癌相关性的研究进展[J]. 实用肿瘤学杂志, 2016, 30(1): 57-60.
[12]	张永健, 刘彦龙, 崔滨滨. 结直肠肿瘤中长链非编码RNA的研究进展[J]. 实用肿瘤学杂志, 2015, 29(6): 553-556.
[13]	黄东宁¹, 梁小娜²综述, 陈罡²审校. 长链非编码RNA在结直肠癌中的研究进展[J]. 实用肿瘤学杂志, 2015, 29(3): 263-266.
[14]	周坤, 姜晓峰, 梁红艳. 羧肽酶E的高表达与肿瘤的生长和转移相关[J]. 实用肿瘤学杂志, 2012, 26(2): 158-161.
[15]	杨兆坤, 娄阁. AEG-1在宫颈癌组织中的表达及临床意义[J]. 实用肿瘤学杂志, 2010, 24(6): 529-532.