放疗同期IP方案化疗治疗局部晚期食管癌临床研究

doi:10.3969/j.issn.1002-3070.2009.02.006

实用肿瘤学杂志 ›› 2009, Vol. 23 ›› Issue (2): 126-129.doi: 10.3969/j.issn.1002-3070.2009.02.006

放疗同期IP方案化疗治疗局部晚期食管癌临床研究

高飞¹, 贾霖¹, 杜辉章², 王允¹, 况小红¹, 韩建军¹

1.四川省绵阳市第三人民医院肿瘤科(绵阳 621000);
2.四川省盐亭县肿瘤医院

收稿日期:2009-01-12 出版日期:2009-04-20 发布日期:2012-02-21
作者简介:高飞, 男, (1979-), 本科, 主治医师, 从事肿瘤内科临床工作

A clinical study of combination of radiotherapy and IP regimen in the treatment of patients with local advanced esophageal cancer

GAO Fei¹, JIA Lin¹, DU Huizhang², WANG Yun¹, KUANG Xiaohong¹, HAN Jianjun¹

1.The Tthird Hospital of Mianyang, Sichuan, 621000;
2.The Tumor Hospital of Yan Ting, Sichuan, 621600

Received:2009-01-12 Online:2009-04-20 Published:2012-02-21

摘要/Abstract

摘要： 目的探讨放疗同期IP方案化疗治疗局部晚期食管癌的临床疗效及毒性反应。方法 68例局部晚期食管癌患者随机分为IP方案同期放疗组(研究组)35例和单纯放疗组(对照组)33例, 两组放疗均采用常规分割放射治疗, 总剂量60Gy, 化疗采用放疗第一天开始伊立替康(国产艾力):65mg/m² ivgtt第1、8天;DDP:30mg/m² ivgtt第1、8天, 每21天为一周期, 共四周期。结果研究组治疗晚期食管癌缓解率(91.4%)明显优于单放组(66.7%), 两年总生存率及一、二年的无疾病进展生存率前者也明显高于后者, 具统计学意义(P＜0.05);IP方案组恶心呕吐、骨髓抑制(白细胞减少)和腹泻的发生率高于单放组。结论 IP方案化疗同期放疗治疗局部晚期食管癌疗效肯定, 能提高生存率, 但毒副反应增加, 患者可耐受, 值得临床推广应用。

Abstract: Objective To study the clinical efficacy and toxicity of combination of the radiotherapy and IP regimen for patients with local advanced esophageal cancer.Methods 68 cases of local advanced esophageal cancer were randomized into two groups, simple irradiation group(control group, n=33)receiving conventional radiotherapy to a total of 60Gy, combined group(research group, n=35)which received the same radiotherapy as simple irradiation group plus chemotherapy with IP regimen, patients in research group were treated with infusion of Irinotecan 65mg/m² and DDP 30mg/m² on day 1, 8.21 days was a cycle and 4 cycles were given.Results The remission rate, one and two year disease-free survival rate in research group were significant higher than that in control group.But the incidence of nausea, vomiting, myelosuppression and diarrhea was higher in research group.Conclusion The efficacy of concomitant radiotherapy and IP regimen for local advanced esophageal cancer is obvious and it can improve the survival rate of patients, which is worthy of clinical application.

中图分类号:

R735.1

高飞, 贾霖, 杜辉章, 王允, 况小红, 韩建军. 放疗同期IP方案化疗治疗局部晚期食管癌临床研究[J]. 实用肿瘤学杂志, 2009, 23(2): 126-129.

GAO Fei, JIA Lin, DU Huizhang, WANG Yun, KUANG Xiaohong, HAN Jianjun. A clinical study of combination of radiotherapy and IP regimen in the treatment of patients with local advanced esophageal cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2009, 23(2): 126-129.

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放疗同期IP方案化疗治疗局部晚期食管癌临床研究

A clinical study of combination of radiotherapy and IP regimen in the treatment of patients with local advanced esophageal cancer

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