Abstract: Objective To investigate different dose of TP regimen of concurrent radiotherapy and chemotherapy combined treatment of locally advanced esophageal cancer efficacy and toxicity.Methods 53 patients with locally advanced esophageal cancer patients were divided into three groups:High doses of paclitaxel plus cisplatin in combination with radiotherapy group(hereinafter referred to as the high dose group:the DDP 100mg/m² d1;PTX175mg/m²,d1)18 cases;Low doses of paclitaxel plus cisplatin combination with radiotherapy group(hereinafter referred to as Low doses Group:DDP 20mg/m² d1-5;of PTX 20mg/m² d1,3,5)16 cases;19 cases of the radiotherapy alone group.Chemotherapy 21 days for a cycle;Radiotherapy using three-dimensional conformal radiotherapy,conventional fractionation,total dose 60Gy/6W.Results The high-dose group,low-ose group,radiotherapy group,complete remission(CR)rate,response rate(CR + PR)and 1-year survival rates were 58.8%,81.3%,26.3%;88.2%,93.8%,57.9 % and 94.1%,100%,73.7%,respectirely.Three groups,high and low dose group,CR rate,CR + PR rate than radiotherapy alone group were significantly different(P＜0.05);low-dose group and radiotherapy group in the 1-year survival difference was statistically significant,P＜0.05.The toxicity of high-dose group in the bone marrow suppression,gastrointestinal reactions,hair loss,the lower dose group and radiotherapy group difference was statistically significant(P＜0.05).Conclusion Small doses of TP chemotherapy with concurrent radiotherapy and the treatment of locally advanced esophageal cancer hare better efficacy,and its toxicity can be tolerated.