Abstract: Objective To investigate the effects of transcutaneous electrical Neiguan acupoint stimulation(TEAS)on postoperative nausea and vomiting(PONV),degree of pain and Mean arterial pressure(MAP)in patients undergoing imitation radical mastectomy.Methods 90 patients,ASA Ⅰ or Ⅱ,who accorded with experiment condition undergoing imitation radical mastectomy,were divided randomly into point group,nonpoint group and control group.The changes of indicators were observed in preoperative,intraoperative and postoperative.Results The significant lower mean arterial pressure was observed in Neiguan acupoint group,compared with non acupoint and control group(P＜0.05).The Mean arterial pressure was not significantly difference between the non-acupoint group and the control group(P＞0.05).The steady decreased trend of mean arterial pressure have been observed with the extension of observation time in the acupoint group.The mean scores of PONV and pain in the control group were significantly higher than in the non-acupoint and the acupuncture groups(P＜0.05).The satisfactory scores of postoperation were significantly higher in the acupoint and the nonacupoint groups than those in the control group(P＜0.05).Conclusion Our findings suggest that the TEAS is more effective in preventing PONV,and there are a better analgesic effect and stable heart rate.