关键词: 晚期胃癌, 奥沙利铂, 亚叶酸钙, 5-氟尿嘧啶, 持续静滴

Abstract: Objective To evaluate the progress and the transfer of FOLFOX6 regimen efficacy and toxicity in gastric cancer.Methods 37 patients with advanced gastric cancer patients were received FOLFOX6 regimen,namely:oxaliplatin 100mg/m² and 5% glucose infusion 250mL 2-hour drip on day 1,leucovorin 400mg/m² and 0.9% saline infusion 250mL 2-hour drip afterwards.It was followed by 5-fluorouracil 400mg/m²,bolus,and micro pumps continuous infusion 2400mg/m² for 46 hours.It was repeated every 2 weeks and 2 times for 1 cycle.Two cycles were used to determine efficacy.Results 37 patients were evaluated(48.6% total efficiency).Period and initial treatment with 66.7% efficiency were re-treated with 40.0% efficiency.The median time for progresion was 5.6 months,and median overall survival was 8.3 months.Toxicity was mainly nausea,vomiting,leukopenia and peripheral neurotoxicity.There was no chemotherapy-related death.Conclusion FOLFOX6 regimen in advanced gastric cancer is effectively and relatively safe.It is worth further studing and active applications.

Key words: Advanced gastric cancer, Oxaliplatin, Leucovorin, 5-Fu, Continuous infusion