Abstract: Human epididymis protein 4(HE4)is one of the most focused tumor markers in the research of gynecology malignancy.Increasing number of studies have shown that HE4 has a good application prospect in early diagnosis,differentiential diagnosis,and diseased surveillance of ovarian cancer.HE4 combined with CA125 can improve the sensitivity and specificity of the diagnosis,and may be helpful in the prognosis assessment of ovarian cancer.It may have wider application field.