Abstract: Objective Retrospective analysis on the efficacy of whether liver cancer g-amma knife radiotherapy combined with hyperthermia is better than the simple radiation therapy.Methods Retrospective analysis of cases were from May 2009 to December 2011 in our Hospital.65 cases of primary liver cancer patients were randomly divided into radiotherapy group(30cases)and combination group(35cases);radiotherapy group was given gamma-ray the r gamma knife radiotherapy;combination group was given the gamma-raythe r gamma knife radiotherapy as well as liver tumor local hyperthermia within one hour after the radiotherapy.We examined the short-term effect, and observed the improvement of life quality, and the survival rate and radiation toxicity after three months.Results Compared with the Gamma knife radiotherapy combined with local hyperthermia treatment and simple radiotherapy of liver cancer, the partial remission rate and symptom relief were higher.Toxicity was lower, and the quality of life was better as well as the total lifetime of OS was slightly longer.Conclusion Gamma knife radiotherapy combined with local hyperthermia is advantage than a simple gamma knife radiotherapy in the area of tumor remission rate, quality of life, toxicity and survival period.