关键词: 甲状腺乳头状癌, 免疫组织化学方法:Fascin蛋白

Abstract:

Objective To investigate the expression of protein fascin in normal thyroid tissues、thyroid benign lesions and thyroid papillary carcinoma and to evaluate their clinical significance.Methods The expression of protein fascin was determined in 60 patients with thyroid papillary carcinoma,40 of thyroid adenoma and nodular goiter and 20 of normal thyroid tissues by histochemical method(SP),then these values were compared among each other.Results The positive rate of fascin protein in thyroid papillary carcinoma(71.67%)was higher than that in thyroid benign lesions and normal thyroid tissues,there was significant difference between them(P＜0.01).The positive rate in thyroid benign lesions was not higher than that in normal thyroid tissues,there was no significant difference(P＞0.05).In thyroid papillary carcinoma with lymphatic metastasis,the positive expression of fascin protein significantly increased(91.30%).There was significant difference compared with no lymphatic metastasis(59.46%),(P＜0.05).Conclusion The expression of fascin protein is correlated to the incidence,invasion and metastasis of thyroid papillary carcinoma and it may provide theoretical evidence for identification between benign diseases and thyroid carcinoma,it is also helpful for evaluating the behaviour of thyroid papillary carcinoma.The potiential of fascin protein as a novel early diagnostic marker and therapeutic target is assessed in thyroid carcinoma.

Key words: Thyroid papillary carcinoma, Immunohistochemistry, Protein fascin