Abstract: Objective To evaluate the role of transrectal ultrasonography(TRUS),serum PSA and relavant parameters in prostate biopsy,investigate the feasibility of individualization of prostate biopsy strategies based on TRUS,serum PSA and relavant parameters.Methods Clinical data of 195 patients who had been carried out the first TRUS guided prostate biopsy were reviewed.The 8-core strategies were chosen in the patients.The suspicious lesions were increased 1-2 points biopsy.The association between prostate cancer(PCa)detection rate and patients'TRUS,PSA levels and relavant parameters was analyzed according to the biopsy results.Results 98 cases(50.3%)had PCa in 195 patients.Of 45 patients with PSA between 4~10ng/mL,16 patients(35.6%)had PCa.Of 10 patients with TRUS(+)and PSATZ≥0.35ng/mL²,all had PCa on pathological positive.Of 150 patients with PSA＞10ng/mL,82 patients(54.7%)had PCa.There were statistical significant differences between the patients with PSA between 4-10ng/mL and PSA＞10ng/ml two groups in the PCa detection rates,it was also found that there was statistical significance between TRUS(+)and TRUS(-).Conclusion Individualization of the prostate biopsy strategies according to TRUS,serum PSA and relavant parameters is feasible.