LSD1在恶性肿瘤中的研究进展

doi:10.11904/j.issn.1002-3070.2014.06.019

Abstract

Abstract:

Lysine specific demethylase 1(LSD1)is a kind of flavin adenine dinucleotid(FAD)dependent amine oxidase and can specifically demethylate H3K4me2/me1 and H3K9me2/mel,thus it can regulate gene transcriptional activity.LSD1 is essential for mammalian development and is involved in many biological processes,including cell differentiation,gene activation,and gene repression.Nowadays,it is demonstrated that LSD1 might promote cell phase transition(deficiency in LSD1 leads to partial cell cycle arrest in G₂/M)and cell proliferation,suggesting that the over-expression of LSD1 might promote tumorigenesis.LSD1,as a demethylase,may be a new target for anti-cancer therapy.Hereby,we review on the structure,action mode of LSD1 and its relationship with oncogenesis.

Key words: LSD1, Demethylation, Malignant tumors

CLC Number:

R730.1

JING Jing,CHEN Gongyan. The research progress of LSD1 in malignant tumors[J]. PRACTICAL ONCOLOGY JOURNAL, 2014, 28(6): 569-572.

References

1 Olins DE,Olins AL.Chromatin history:our view from the bridge[J].Nat Rev Mol Cell Biol,2003,4(10):809-814.
2 Shi Y,Lan F,Matson C,et al.Histone demethylation mediated by the nuclear amine oxidase homolog LSD1[J].Cell,2004,119(7):941-953.
3 Wang J,Scully K,Zhu X,et al.Opposing LSD1 complexes function in developmental gene activation and repression programmes[J].Nature,2007,446(7138):882-887.
4 Scoumanne A,Chen X.The lysine-specific demethylase 1 is required for cell proliferation in both p53-dependent and-independent manners[J].Biol Chem,2007,282(21):15471-15475.
5 Culhane JC,Cole PA.LSD1 and the chemistry of histone demethylation[J].Curr Opin Chem Biol,2007,11(5):561-568.
6 Aravind L,Iyer LM.The SWIRM domain:a conserved module found in chromosomal proteins points to novel chromatin-modifying activities[J].Genome Biol,2002,3(8):391-397.
7 Yang M,Gocke CB,Luo X,et al.Structural basis for CoREST-dependent demethylase of nucleosomes by the human LSD1 histone demethylase[J].Mol Cell,2006,23(3):377-387.
8 Stavropoulos P,Blobel G,Hoelz A.Crystal structure and mechanism of human lysine-specific demethylase-1[J].Nat Struct Mol Biol,2006,13(7):626-632.
9 Binda C,Mattevi A,Edmondson DE.Structure-function relationship in flavoenzyme-dependent amine oxidations:a comparion of polyamine oxidase an monoamine oxidase[J].J Biol Chem,2002,277(6):23973-23976.
10 Binda C,Newton-Vinson P,Hubalek F,et al.Structure of human monoamine oxidase B,a drug target for the treament of neurological disorders[J].Nat Struct Biol,2002,9(1):22-26.
11 Lee MG,Wynder C,Cooch N,et al.An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation[J].Nature,2005,437(7057):432-435.
12 Anand R,Marmorstein R.Structure and mechanism of lysine-specific demethylase enzymes[J].J Biol Chem,2007,282(49):35425-35429.
13 Huang J,Sengupta R,Espejo AB,et al.p53 is regulated by the lysine demethylase LSD1[J].Nature,2007,449(7158):105-108.
14 Wang J,Hevi S,Kurash JK,et al.The lysine demethylase LSD1(KDM1)is required for maintenance of global DNA methylation[J].Nat Genet,2009,41(1):125-129.
15 Chen T,Li E.Establishment and maintenance of DNA methylation patterns in mammals[J].Curr Top Microbiol Immunol,2006,301(5):179-201.
16 Lan W,Zhang D,Jiang J.The roles of LSD1-mediated epigenetic modifications in maintaining the pluripotency of bladder cancer stem cells[J].Med Hypotheses,2013,81(5):823-825.
17 Siegel R,Naishadham D,Jemal A.Cancer statistics,2012[J].CA Cancer J Clin,2012,62(1):10-29.
18 Kashyap V,Ahmad S,Nilsson EM,et al.The lysine specific demethylase-1(LSD1/KDM1A)regulates VEGF-A expression in prostate cancer[J].Mol Oncol,2013.7(3):555-566.
19 Banerjee S,Kaye SB.New strategies in the treatment of ovarian cancer:current clinical perspectives and future potential[J].Clin Cancer Res,2013,19(5):961-968.
20 Konovalov S,Garcia-Bassets I.Analysis of the levels of lysine-specific demethylase 1(LSD1)mRNA in human ovarian tumors and the effects of chemical LSD1 inhibitors in ovarian cancer cell lines[J].J Ovarian Res,2013,6(1):75-90.
21 Schütte K,Bornschein J,Malfertheiner P.Hepatocellular carcinoma-epidemiological trends and risk factors[J].Dig Dis,2009,27(2):80-92.
22 Zhao ZK,Dong P,Gu J,et al.Overexpression of LSD1 in hepatocellular carcinoma:a latent target for the diagnosis and therapy of hepatoma[J].Tumour Biol,2013,34(1):173-180.
23 Piperi C,Vlastos F,Farmaki E,et al.Epigenetic effects of lung cancer predisposing factors impact on clinical diagnosis and prognosis[J].J Cell Mol Med,2008,12(5):1495-1501.
24 Seligson DB,Horvath S,McBrian MA,et al.Global levels of histone modifications predict prognosis in different cancers[J].Am J Pathol,2009,174(5):1619-1628.
25 Lv T,Yuan D,Miao X,et al.Over-expression of LSD1 promotes proliferation,migration and invasion in non-small lung cancer[J].PLoS One,2012,7(4):e35065.
26 田振囡,胡杨.青年乳腺癌病理特点-附60例病例分析[J].实用肿瘤学杂志,2007,21(4):338-341.
27 Lim S,Janzer A,Becker A,et al.Lysine-specific demethylase 1(LSD1)is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology[J].Carcinogenesis,2010,31(3):512-520.
28 Serce N,Gnatzy A,Steiner S,et al.Elevated expression of LSD1(Lysine-specific demethylase)during tumour progression from pre-invasive to invasive ductal carcinoma of the breast[J].BMC Clin Pathol,2012,12(6):13-17.
29 于妍妍,王斌,陈东风.LSD1及其在肿瘤发生中的调节作用[J].医学综述,2012,18(17):2787-2790.
30 Xu G,Xiao Y,Hu J,et al.The combined effect of retinoic acid and LSD1 siRNA inhibition on cell death in the human neuroblastoma cell line SH-SY5Y[J].Cell Physiol Biochem,2013,31(6):854-862.
31 Singh MM,Manton CA,Bhat KP,et al.Inhibition of LSD1 sensitizes glioblastoma cells to histone deacetylase inhibitors[J].Neuro Oncol,2011,13(8):894-903.

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The research progress of LSD1 in malignant tumors

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