Snail调控肿瘤细胞上皮间质转化的相关信号通路

doi:10.11904/j.issn.1002-3070.2014.06.020

Abstract

Abstract:

Tumor metastasis and invasion of cancer are the leading causes of death in patients.The processes of tumor metastasis and invasion involves a variety of factors in which epithelial-to-myofibroblast transition(EMT)plays an important role.Transcription factor Snail as EMT of tumor cell key regulator has played an important role.Through the study of Snail regulating EMT of tumor cell signaling pathways will help us understand the mechanisms of tumor invasion and metastasis better and provide a basis for finding effective targets.

Key words: Snail, EMT, Cancer

CLC Number:

R730.261

JIANG Yang,GENG Jingshu. Snail regulate tumor cell epithelial-to-myofibroblast transition related signaling pathways[J]. PRACTICAL ONCOLOGY JOURNAL, 2014, 28(6): 573-576.

References

1 Ruiz P,Gunthert U.The cellular basis of metastasis[J].World J Urol,1996,14(3):141-150.
2 Ikenouchi J,Matsuda M,Furuse M,et al.Regulation of tight junctions during the epithelium-mesenchyme transition:direct repression of the gene expression of claudins/occludin by Snail[J].J Cell Sci,2003,116(Pt 10):1959-1967.
3 Cardiff RD.Epithelial to Mesenchymal transition tumors:fallacious or Snail′s pace[J].Clin Cancer Res,2005,11(24 Pt 1):8534-8537.
4 Thuault S,Valcourt U,Petersen M,et al.Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition[J].J Cell Biol,2006,174(2):175-183.
5 Brandl M,Seidler B,Haller F,et al.IKK(alpha)controls canonical TGF(ss)-SMAD signaling to regulate genes expressing SNAIL and SLUG during EMT in panc1 cells[J].J Cell Sci,2010,123(Pt 24):4231-4239.
6 Medici D,Potenta S,Kalluri R.Transforming growth factor-beta2 promotes Snail-mediated endothelial-mesenchymal transition through convergence of Smad-dependent and Smad-independent signalling[J].Biochem J,2011,437(3):515-520.
7 Hudson LG,Choi C,Newkirk KM,et al.Ultraviolet radiation stimulates expression of Snail family transcription factors in keratinocytes[J].Mol Carcinog,2007,46(4):257-268.
8 Sun S,Ning X,Zhai Y,et al.Egr-1 Mediates chronic hypoxia-induced renal interstitial fibrosis via the PKC/ERK pathway[J]Am J Nephnol,2014,39(5):436-448.
9 Strippoli R,Benedicto I,Perez LM,et al.Epithelial-to-mesenchymal transition of peritoneal mesothelial cells is regulated by an ERK/NF-kappaB/Snail1 pathway[J].Dis Model Mech,2008,1(4-5):264-274.
10 Barbera MJ,Puig I,Dominguez D,et al.Regulation of Snail transcription during epithelial to mesenchymal transition of tumor cells[J].Oncogene,2004,23(44):7345-7354.
11 Julien S,Puig I,Caretti E,et al.Activation of NF-kappaB by Akt upregulates Snail expression and induces epithelium mesenchyme transition[J].Oncogene,2007,26(53):7445-7456.
12 Zhang K,Zhaos J,Liu X,et al.Activation of NF-κB upregulates Snail and consequent repression of E-cadherin in cholangiocarcinoma cell invasion[J].Hepatogastroenterology,2011,58(105):1-7.
13 Zhuo W,Wang Y,Zhuo X,et al.Knockdown of Snail,a novel zinc finger transcription factor,via RNA interference increases A549 cell sensitivity to cisplatin via JNK/mitochondrial pathway[J].Lung Cancer,2008,62(1):8-14.
14 Hudson LG,Choi C,Newkirk KM,et al.Ultraviolet radiation stimulates expression of Snail family transcription factors in keratinocytes[J].Mol Carcinog,2007,46(4):257-268.
15 Marchetti A,Colletti M,Cozzolino AM,et al.ERK5/MAPK is activated by TGFbeta in hepatocytes and required for the GSK-3beta-mediated Snail protein stabilization[J].Cell Signal,2008,20(11):2113-2118.
16 Stemmer V,Craene B,Berx G,et al.Snail promotes Wnt target gene expression and interacts with beta-catenin[J].Oncogene,2008,27(37):5075-5080.
17 Yook JI,Li XY,Ota I,et al.Wnt-dependent regulation of the E-cadherin repressor snail[J].J Biol Chem,2005,280(12):11740-11748.
18 Katoh M,Katoh M.Cross-talk of WNT and FGF signaling pathways at GSK3beta to regulate beta-catenin and SNAIL signaling cascades[J].Cancer Biol Ther,2006,5(9):1059-1064.
19 Cho HJ,Baek KE,Saika S,et al.Snail is required for transforming growth factor-beta-induced epithelial-mesenchymal transition by activating PI3 kinase/Akt signal pathway[J].Biochem Biophys Res Commun,2007,353(2):337-343.
20 Pon YL,Zhou HY,and Cheung AN,et al.P70 S6 kinase promotes epithelial to mesenchymal transition through snail induction in ovarian cancer cells[J].Cancer Res,2008,68(16):6524-6532.
21 Walker AJ,Lacchini AH,Sealey KL,et al.Spreading by snail(Lymnaea stagnalis)defence cells is regulated through integrated PKC,FAK and Src signalling[J].Cell Tissue Res,2010,341(1):131-145.
22 Bachelder RE,Yoon SO,Franci C,et al.Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription:implications for the epithelial-mesenchymal transition[J].J Cell Biol,2005,168(1):29-33.
23 Schaeffer DF,Assi K,Chan K,et al.Tumor expression of integrin-linked kinase(ILK)correlates with the expression of the E-cadherin repressor snail:an immunohistochemical study in ductal pancreatic adenocarcinoma[J].Virchows Arch,2010,456(3):261-268.
24 Wu Y,Zhou BP.Snail:More than EMT[J].Cell Adh Migr,2010,4(2):199-203.
25 Saad SR,Yong R.Notch mediated epithelial to mesenchymal transformation is associated with increased expression of the Snail transcription factor[J].Int J Biochem Cell Biol,2010,42(7):1115-1122.
26 Grego-Bessa J,Diez J,Timmerman L,et al.Notch and epithelial-mesenchyme transition in development and tumor progression:another turn of the screw[J].Cell Cycle,2004,3(6):718-721.

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Snail regulate tumor cell epithelial-to-myofibroblast transition related signaling pathways

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