Abstract: Objective To explore the expression and correlation of CIP2A and HPV16-E7 protein in cervical cancer.Methods The expressions of CIP2A and HPV16-E7 in 50 cases of cervical cancer,34 cases of CINⅠ,40 cases of CINⅡ,45 cases of CINⅢ and 12 cases of normal tissues were assessed by immunohistochemical method.Results The rate of expressions of CIP2A protein in cancer tissues and CINⅢ were 68%(34/50)and 13.3%(6/45)respectively;The rate of expressions of CIP2A protein in CINⅡ、CINⅠ tissues and normal tissues were negative.The expressions of CIP2A protein in cancer tissues were stronger than in CIN tissues and normal tissues(P＜0.05)and closely correlated with histologic grade,TNM stage and lymph node metastasis(P＜0.05).The rates of expressions of HPV16-E7 protein in cancer tissues CINⅢ,CINⅡand CINⅠ were 72%(36/50),68.89%(31/45),67.50%(27/40)and 64.71%(22/34)respectively.The rate of expressions of HPV16-E7 protein in normal tissues was 16.67%(2/12);The expressions of HPV16-E7 protein in cancer tissues and in CIN tissues were stronger than in normal tissues(P＜0.05)and closely correlated with age,but were not correlated with histologic grade,TNM stage and lymph node metastasis(P＞0.05).The expression of CIP2A was positively associated with the expression of HPV16-E7 in cervical cancer(r=0.514,P＜0.05).Conclusion The expressions of CIP2A and HPV16-E7 are very strong in cervical cancer;CIP2A and HPV16 may play important roles in the carcinogenesis and the development of cervical cancer.