Abstract: The primary transitional cell carcinoma in nasal cavity is clinically manifested by progessively increasing nasal decongestion,bloody and purulent secretion intermittent appear,headaches,hearing loss.The macroscopic character showed that a medium gray red ground tissue.The tumor cells were arranged in nested,papillary by microscopy,the nucleus was round or oval shape,the tumor cells was infiltrating growth,basophilia or bright.Immunhistochenmical showed that P63,CK5/6,CK18,UroplakinIII,CerbB-2,CEA were positive,Ki67 positive index was about S-100,Cga,Syn,Calponinare all tested negative.Nasal primary transitional cell carcinoma is uncommon clinically,and it is easy to misdiagnosed.Its diagnosis and differential diagnosis mainly depends on pathological histoloy and immunohistochenmical examination.