表观基因组研究揭示23个由DNA甲基化异常介导的乳腺癌致病基因的研究

doi:10.11904/j.issn.1002-3070.2015.04.003

Abstract

Abstract: Objective To identify and analyze the DNA methylation induced pathogenic genes in breast cancer.Methods Using genomic data provided by the international cancer genome,we carried out systematic analysis of the abnormal gene expression in breast cancer and epigenetic regulation mechanism by bioinformatics Methods .Results We identified 428 genes with abnormal expressions in breast cancer by t test.Functional enrichment analysis revealed genes up-regulation in breast cancer were closely related to the cell cycle,and those down-regulated were significantly enriched in the hormone response function.Study on DNA methylation revealed that breast cancer showed an unique DNA methylation pattern.Further analysis reveals 23 breast cancer genes induced by abnormal DNA methylation.Conclusion DNA methylation can mediate the abnormal expression of breast cancer genes,and is an important biological marker for early diagnosis and prognosis of breast cancer.

Key words: Breast cancer, DNA methylation, Differentially expressed gene

CLC Number:

R737.9

LIU Xiaojuan,CHEN Wenjie,LIU Hongbo,ZHANG Jinming,ZHANG Yan. Epigenomic analysis reveals 23 breast cancer pathogenic genes induced by aberrant DNA methylation[J]. PRACTICAL ONCOLOGY JOURNAL, 2015, 29(4): 299-304.

References

1 Gyorffy B,Lanczky A,Eklund AC,et al.An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients[J].Breast Cancer Res Treat,2010,123(3):725-731.
2 Alco G,Bozdogan A,Selamoglu D,et al.Clinical and histopathological factors associated with Ki-67 expression in breast cancer patients[J].Oncol Lett,2015,9(3):1046-1054.
3 Zheng Y,Huo D,Zhang J,et al.Microsatellites in the estrogen receptor(ESR1,ESR2)and androgen receptor(AR)genes and breast cancer risk in African American and Nigerian women[J].PLoS One,2012,7(7):e40494.
4 Shaaban AM,Sloane JP,West CR,et al.Breast cancer risk in usual ductal hyperplasia is defined by estrogen receptor-alpha and Ki-67 expression[J].Am J Pathol,2002,160(2):597-604.
5 王泽涛,吕付龙,王劲松.表观遗传学对乳腺癌雌激素受体-α的调控[J].实用肿瘤学杂志,2014,28(3):268-271.
6 Nickell A,Burke NJ,Cohen E,et al.Educating low-SES and LEP survivors about breast cancer research:pilot test of the Health Research Engagement Intervention[J].J Cancer Educ,2014,29(4):746-752.
7 Noh JH,Ryu SY,Eun JW,et al.Identification of large-scale molecular changes of Autotaxin(ENPP2)knock-down by small interfering RNA in breast cancer cells[J].Mol Cell Biochem,2006,288(1-2):91-106.
8 Endogenous H,Collaborative G,Key TJ,et al.Insulin-like growth factor 1(IGF1),IGF binding protein 3(IGFBP3),and breast cancer risk:pooled individual data analysis of 17 prospective studies[J].Lancet Oncol,2010,11(6):530-542.
9 Huang O,Jiang M,Zhang X,et al.Grb14 as an independent good prognosis factor for breast cancer patients treated with neoadjuvant chemotherapy[J].Jpn J Clin Oncol,2013,43(11):1064-1072.
10 Curtis C,Shah SP,Chin SF,et al.The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups[J].Nature,2012,486(7403):346-352.
11 Liu H,Chen Y,Lv J,et al.Quantitative epigenetic co-variation in CpG islands and co-regulation of developmental genes[J].Sci Rep,2013,3(2576):1-10.
12 Xu S,Yang Y,Tao W,et al.Tamoxifen adherence and its relationship to mortality in 116 men with breast cancer[J].Breast Cancer Res Treat,2012,136(2):495-502.

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Epigenomic analysis reveals 23 breast cancer pathogenic genes induced by aberrant DNA methylation

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