RASSF1A及其甲基化与乳腺癌的关系

doi:10.11904/j.issn.1002-3070.2015.04.019

Abstract

Abstract: Breast cancer is one of the most common malignant tumors in women.Early diagnosis plays a very important role in the treatment of breast cancer.Recently,with the development of epigenetics,it gives us a new orientation for early detection for cancers.The most understood mechanism of epigenetics is DNA methylation.Ras associated domain family 1A gene(RASSFlA)promoter methylation occurres in tumor′s early stage,and have a statistically concern with tumor′s TNM stage,invasiveness and outcomes.Moreover,DNA methylation can be reversed,so RASSF1A can be a promising candidate for early breast cancer detection biomarker,and can be a potential orientation for breast cancer treatment.

Key words: Breast cancer, DNA methylation, RASSF1A, Estrogen receptor-α

CLC Number:

R737.9

LV Fulong,WANG Zetao,WANG Jinsong. RASSF1A and RASSF1A methylation′s relationship with breast cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2015, 29(4): 372-375.

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RASSF1A and RASSF1A methylation′s relationship with breast cancer

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