SPOCK1蛋白结构和功能与肿瘤的研究进展

doi:10.11904/j.issn.1002-3070.2015.04.021

Abstract

Abstract: Testicular proteoglycan 1(SPOCK1),a kind of extracellular matrix glycoprotein,can inhibit the activity of cathepsin and promotes the combination of low affinity for calcium.SPOCK1 is essential to the development of mammals.It not only regulates cell,and the interactions between cells and matrix are also related to cell migration and proliferation.Currently,SPOCK1is confirmed that expression can promote the occurrence and development of tumor,suggesting it could be a new anti-tumor target.This article is to review SPOCK1 molecular structure,biological function and its relationship with tumor.

Key words: SPOCK1, Proteoglycan, Extracellular matrix, Tumor

CLC Number:

R730.43

GUO Haonan,PENG Shiyun. The research progression on SPOCK1 and tumor[J]. PRACTICAL ONCOLOGY JOURNAL, 2015, 29(4): 380-384.

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The research progression on SPOCK1 and tumor

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