散发性结直肠癌的分子机制研究进展

doi:10.11904/j.issn.1002-3070.2015.05.019

Abstract

Abstract: Colorectal cancer(CRC)is one of the most common tumor,which has complicated pathogenesis.it is estimated that the vast majority of CRCs is non-hereditary“sporadic cancers”with no apparent evidence of an inherited component.Sporadic CRC Results from the cumulative effects of multiple genetic and epigenetic alterations caused by somatic mutations,which may be the indirect result of several environmental factors themselves.There are at least 3 major genetic alternations that lead to colorectal carcinogenesis:(1)The chromosomal instability(CIN)pathway;(2)The microsatellite instability(MSI)pathway;(3)The cytosine-phospho-guanine(CpG)island methylator phenotype(CIMP)pathway,while DNA methylation,modifications in histone proteins and microRNAs(miRNAs)are analyzed in the field of epigenetic alterations.This review summarizes the newest biomolecular progression involved in CRC pathogenesis,for the purpose of improving strategy for prevention,surveillance,early diagnosis and therapy.

Key words: Colorectal cancer, The chromosomal instability, Microsatellite instability, Cytosine-phospho-guanine island methylator phenotype, DNA methylation

CLC Number:

R735.3

FENG Yingying, DING Jianhua, ZHAO Ke. Research progress on molecular mechanism of sporadic colorectal cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2015, 29(5): 471-475.

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Research progress on molecular mechanism of sporadic colorectal cancer

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