Abstract: Objective To analyze the value of diffusion weighted imaging(DWI)in assessing the effect of neoadjuvant chemotherapy of uterine cervix cancer.Methods Thirty one patients with LACC confirmed by pathology received conventional magnetic resonance imaging and DWI before and after neoadjuvant chemotherapy.The variation of DWI image and ADC was evaluated before and after chemotherapy.Results The correlation between maximum diameter of the tumor before treatment(37.10±11.23)and pretreatment ADC value(0.83±0.12)was not statistically significant(correlation coefficient r=-0.1746,P=0.3475);the correlation between the maximum diameter of the tumor(24.03±5.65)and ADC value(1.10±0.16)after treatment was not statistically significant(correlation coefficient r=-0.2077,P=0 2621.);the degree of tumor size before and after the treatment was correlated with the degree of ADC increase(P＜ 0.05);Effective chemotherapy group of 20 cases,invalid group of 11 cases,ADC value of effective treatment group after treatment(0.95±0.13)was significantly higher than ADC value before chemotherapy(0.80±0.12),the change was statistically significant(P＜0.05),while the difference between former ADC value(0.88±0.10)and ADC value after treatment(0.95±0.13)of ineffective group therapy was not statistically significant(P＞0.05).Conclusion DWI sequence may be useful for early prediction and evaluation of curative effect to neoadjuvant chemotherapy for uterine cervical cancer.

Key words: Magnetic resonance lmaging(MRI), Diffusion weighted imaging, Uterine cervix cancer, Neoadjuvant chemotherapy