结直肠肿瘤中长链非编码RNA的研究进展

doi:10.11904/j.issn.1002-3070.2015.06.016

Abstract

Abstract: Many long non-coding RNA(lncRNA)has been found in recent years.The abnormal lncRNA expression is closely related to the occurrence and development of tumor.LncRNA can be divided into the tumor promoting and tumor inhibiting according to the function.lncRNA generally overexpresses in solid tumor tissue,acts as an important factor involved in tumor invasion,proliferation and metastasis,and has been associated with prognosis of neoplasm.This paper describes the current situation of lncRNA research.We mainly introduce several functions of lncRNA which thoroughly researched at present(such as HOTAIR,H19,MALAT-1,LincRNA-p21,GAS5,etc)and their expression in colorectal tumor tissue,indicating that regulating the expression level of lncRNA may provide a new basis for the diagnosis and treatment of colorectal cancer.

Key words: Long non-coding RNA(LncRNA), Colorectal cancer, Gene regulation

CLC Number:

R735.3⁺4

ZHANG Yongjian, LIU Yanlong, CUI Binbin. Progress in long non-coding RNA of colorectal cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2015, 29(6): 553-556.

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Progress in long non-coding RNA of colorectal cancer

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