MicroRNA-7与肺癌关系的研究进展

doi:10.11904/j.issn.1002-3070.2016.01.010

Abstract

Abstract: MicroRNA-7(miR-7)was firstly found in Drosophila melanogaster,which participated in the formation of Drosophila wings,eggs and so on.In human being miR-7 is not only involved in cell proliferation and differentiation,but also plays an important role in the development of tumor,especially in lung cancer.Most studies report that miR-7 is low expression in lung cancer with poor prognosis.Improving the expression of miR-7 can inhibit tumor growth.MiR-7 can regulate the expression of BCL-2,EGFR negatively,meanwhile it can regulate the sensitivity of tumor cells to radiotherapy chemotherapy and targeted therapy.Therefore,as a tumor suppressor,miR-7 is expected to become a new target for treatment of lung cancer.

Key words: MicroRNAs, miR-7, Lung cancer

CLC Number:

R734.2

CHEN Yanyan, LIAO Jiao, ZHAO Yuxia. Progress in research on relationship between microRNA-7 and lung cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2016, 30(1): 48-52.

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Progress in research on relationship between microRNA-7 and lung cancer

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