Girdin蛋白与乳腺癌相关性的研究进展

doi:10.11904/j.issn.1002-3070.2016.01.012

Abstract

Abstract: Girdin protein is a kind of actin binding protein,which has the complex molecular structure and takes part in a variety of signaling pathways related with causing cancer.The biological characteristics of Girdin protein have close association with the proliferation and invasion of malignant tumor.Recent studies have shown that Girdin protein is closely related with occurrence and progress of breast cancer.Girdin protein expression in breast cancer cells can not only promote the progress of breast cancer,but also affect the lymph node metastasis and prognosis.Therefore Girdin protein is expected as an independent biomarker to provide a new direction for breast cancer treatment.

Key words: Girdin, Breast cancer, Biomarker

CLC Number:

R737.9

ZHOU Jing, LI Zhigao. Advances on correlation between Girdin protein and breast cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2016, 30(1): 57-60.

References

1 Dowling EC,Klabunde C,Patnick J,et al.Breast and cervical cancer screening programme implementation in 16 countries[J].J Med Screen,2010,17(3):139-146.
2 Garcia-Marcos M,Ghosh P,Farquhar MG.GIV/Girdin transmits signals from multiple receptors by triggering trimeric G protein activation[J].J Biol Chem,2015,290(11):6697-6704.
3 Cao K,Lu C,Han S,et al.Expression of Girdin in primary hepatocellular carcinoma and its effect on cell proliferation and invasion[J].Int J Clin Exp Pathol,2015,8(1):551-559.
4 Wang C,Lin J,Li L,et al.Expression and clinical significance of girdin in gastric cancer[J].Mol Clin Oncol,2014,2(3):425-428.
5 Enomoto A,Ping J,Takahashi M.Girdin,a novel actin-binding protein,and its family of proteins possess versatile functions in the Akt and Wnt signaling pathways[J].Ann N Y Acad Sci,2006,1086(1):169-184.
6 王静,谷峰,马勇杰.Girdin蛋白与肿瘤转移相关性的研究进展[J].中华肿瘤防治杂志,2010,17(3):233-236.
7 郑博文,瞿红叶.Girdin蛋白与恶性肿瘤关系的研究进展[J].皮肤病与性病,2014,36(5):274-276.
8 Ha A,Polyanovsky A,Avidor-Reiss T.Drosophila hook-related protein(girdin)is essential for sensory dendrite formation[J].Genetics,2015,200(4):1149-1159.
9 尹秀花,曲晓媛,姜平.Girdin蛋白在肿瘤中的作用[J].医学综述,2012,18(6):873-875.
10 Jin F,Liu C,Guo Y,et al.Clinical implications of Girdin and PI3K protein expression in breast cancer[J].Oncol Lett,2013,5(5):1549-1553.
11 Ghosh P,Garcia-Marcos M,Farquhar MG.GIV/Girdin is a rheostat that fine-tunes growth factor signals during tumor progression[J].Cell Adh Migr,2011,5(3):237-248.
12 Yamamura Y,Asai N,Enomoto A,et al.Akt-Girdin signaling in cancer-associated fibroblasts contributes to tumor progression[J].Cancer Res,2015,75(5):813-823.
13 Jin SY,Lee HS,Kim EK,et al.Reactive oxygen species and PI3K/Akt signaling in cancer[J].Free Radic Biol Med,2014,75(1):34-35.
14 Jiang P,Enomoto A,Jijiwa M,et al.An actin-binding protein Girdin regulates the motility of breast cancer cells[J].Cancer Res,2008,68(5):1310-1318.
15 Shibata T,Matsuo Y,Shamoto T,et al.Girdin,a regulator of cell motility,is a potential prognostic marker for esophageal squamous cell carcinoma[J].Oncol Rep,2013,29(6):2127-2132.
16 朱明文,孙欣,林方才.Girdin蛋白与乳腺癌复发转移危险度的关系[J].医学研究生学报,2014,27(1):70-72.
17 李晓凤,张璐琪,白雪峰,等.乳腺癌组织中Tuberin和磷酸化Girdin蛋白的表达及临床意义[J].中国肿瘤临床与康复,2014,21(10):1153-1157.
18 Ling Y,Jiang P,Cui SP,et al.Clinical implications for girdin protein expression in breast cancer[J].Cancer Invest,2011,29(6):405-410.
19 Nishimae K,Tsunoda N,Yokoyama Y,et al.The impact of Girdin expression on recurrence-free survival in patients with luminal-type breast cancer[J].Breast Cancer,2015,22(5):445-451.
20 Liu C,Zhang Y,Xu H,et al.Girdin protein:a new potential distant metastasis predictor of breast cancer[J].Med Oncol,2012,29(3):1554-1560.
21 Wang A,Wang J,Sun L,et al.Expression of tumor necrosis factor receptor-assicated factor 4 correlates with expression of Girdin and promotes nuclear translocation of Girdin in breast cancer[J].Mol Med Rep,2015,11(5):3635-3641.
22 Peng WT,Hu X,Yao L,et al.Elevated expression of Girdin in the nucleus indicates worse prognosis for patients with estrogen receptor-positive breast cancer[J].Ann Surg Oncol,2014,21(4):648-656.
23 Parikh PM,Gupta S,Dawood S,et al.ICON 2013:practical consensus recommendations for hormone receptor-positive Her2-negative advanced or metastatic breast cancer[J].Indian J Cancer,2014,51(1):73-79.
24 许允,付丽,谷峰,等.磷酸化Girdin蛋白在乳腺癌中的表达及意义[J].中华肿瘤杂志,2012,34(3):205-209.

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Advances on correlation between Girdin protein and breast cancer

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