MMP-7在非小细胞肺癌中的研究进展

doi:10.11904/j.issn.1002-3070.2016.01.020

Abstract

Abstract: Lung cancer is one of the most common malignant tumors in the world.Non-small lung cancer(NSCLC)accounts for approximately 85%,but its pathogenesis has not been elucidated.As a family of soluble enzymes,matrix metalloproteinases(MMPs)can degrade the constituents of the extracellular matrix(ECM)and the basement-membrane,members share common structural features and are responsible for the relative specific substrates.Some researches show that the matrix metalloproteinases 7(MMP-7)involve in the invasion and metastasis of NSCLC,the expression of MMP-7 in the tissue of NSCLC is significcantly higher than that in adjacent tissues,and the MMP-7 plays important roles in prognosis evaluation of NSCLC patients.Therefore this paper summarize the domain structure,function,regulation and research in NSCLC about MMP-7.

Key words: Matrix metalloproteinases7, Lung cancer, Invasion, Metastasis

CLC Number:

R734.2

SUN Xi, LIU Baogang. Research progress of MMP-7 in non-small lung cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2016, 30(1): 93-96.

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Research progress of MMP-7 in non-small lung cancer

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