Abstract: Objective To explore the clinical characteristics and the influence factors of prognosis of advanced ovarian cancer patients after abdominal metastases.Methods We retrospectively analyzed 65 cases during January 2013 to January 2016 in the First People′s Hospital of Tianmen.The patients were diagnosed clearly with pathological,diagnosed for the first time and has the complete clinical data including peritoneal metastases in 58 cases,which were analyzed for single factor and multiple factors of influencing factors survival analysis.Results 58 cases of patients with diagnosis of peritoneal metastasis in ovarian cancer that the average is(49.2±6.5),from ovarian cancer diagnosis to abdominal metastases for an average time of 11 months,ovarian cancer patients with peritoneal metastasis of the median survival time was 8 weeks,but 7 cases without abdominal metastases that the median survival time was 15 weeks.The single factor survival curves(Kaplan-meier)showed that marital status,reproductive history,history of breastfeeding,malignant ascites,neoadjuvant chemotherapy,comprehensive treatment(chemotherapy and tumor cells to destroy the loss and laparotomy abdominal hot perfusion chemotherapy),peritoneal metastasis tumor number,residual lesion size,quality of life in patients with residual lesions(KPS scores),D-dimer level in plasma and urine trace albumin levels related to the prognosis of patients(P＜0.05).Conclusion Patients with advanced ovarian cancer patients with peritoneal metastasis survival time is shorter,and also company with poor prognosis;Neoadjuvant chemotherapy combined tumor cells to destroy the loss and postoperative intraperitoneal hot perfusion chemotherapy,short-term curative effect is good,it can not only improve the advanced ovarian cancer treatment effectiveness,but also improve the quality of life in patients of late phase.The D-dimer level in plasma and urine trace albumin levels before treatment have remained in the patients with high level or not reduce,treatment effect and prognosis was poor.These can be used as a new index of judging prognosis.

Key words: Ovarian cancer, Abdominal cavity metastasis, Prognosis