Notch基因通路与恶性肿瘤的进展

doi:10.11904/j.issn.1002-3070.2017.01.012

Abstract

Abstract: Notch signaling is one of the most important signaling pathways in vertebrates and invertebrates.It regulates apoptosis,proliferation,differentiation and so on.The up-regulation,down-regulation or structural changes of Notch signal are closely related to the development of various malignant tumors.In the present study,four Notch phenotypes(Notch1-4)have been identified,which bind to their ligands respectively(Jagged1,Jagged2,Delta1,Delta3,Delta4).Notch plays an important role in a variety of malignant tumors.This review focuses on the role of Notch in a variety of solid malignancies,including its role in the process of tumor development and treatment.

Key words: Notch, Malignant tumors, Progression, Treatment

CLC Number:

R730.58

FAN Mingxv, ZHAO Yanbin, LI Boyang, WANG Yan. Research progress in the Notch pathway in malignant tumors[J]. PRACTICAL ONCOLOGY JOURNAL, 2017, 31(1): 57-60.

References

1 Andersson ER,Lendahl U.Therapeutic modulation of Notch signaling-are we there yet[J].Nat Rev Drug Discov,2014,13(5):357-378.
2 Chikara S,Reindl KM.Notch signaling:a hero or villain in the war against cancer[J].Transl Lung Cancer Res,2013,2(6):449-451.
3 Shao H,Huang Q,Liu ZJ.Targeting Notch signaling for cancer therapeutic intervention[J].Adv Pharmacol,2012,65(2):191-234.
4 Espinoza I,Miele L.Notch inhibitors for cancer treatment[J].Pharmacol Therapeut,2013,139(3):95-110.
5 Heuss SF,Ndiaye-Lobry D,Six EM,et al.The intracellular region of Notch ligands Dll1 and Dll3 regulates their trafficking and signaling activity[J].PNAS,2008,105(32):11212-11217.
6 Bridges E,Oon CE,Harris A.Notch regulation of tumor angiogenesis[J].Future Oncology,2011,7(4):569-588.
7 刘兆国,朱智杰,周梁,等.Notch信号通路与肿瘤研究[J].中国药理学通报,2012,28(8):1045-1048.
8 Siegel RL,Miller KD,Jemal A.Cancer statistics,2015[J].Ca Cancer J Clin,2014,64(1):9-29.
9 Gallahan D,Callahan R.Mammary tumorigenesis in feral mice:identification of a new INT locus in mouse mammary tumor virus(Czech II)-induced mammary tumors[J].J Virol,1987,61(1):66-74.
10 Beaulieu N.Involvement of Notch1 in the development of mouse mammary tumors[J].Oncogene,1999,18(44):5973-5981.
11 Pei J,Wang B.Notch-1 promotes breast cancer cells proliferation by regulating LncRNA GAS5[J].Int J Clin Exp Med,2014,8(8):14464-14471.
12 Kim B,Stephen SL,Hanby AM,et al.Chemotherapy induces Notch1-dependent MRP1 up-regulation,inhibition of which sensitizes breast cancer cells to chemotherapy[J].BMC Cancer,2015,15(1):1-12.
13 Hassan WA,Yoshida R,Kudoh S,et al.Notch1 controls cell invasion and metastasis in small cell lung carcinoma cell lines[J].Lung Cancer,2014,86(3):304-310.
14 Hassan WA,Yoshida R,Kudoh S,et al.Notch1 controls cell chemoresistance in small cell lung carcinoma cells[J].Thorac Cancer,2016,7(1):123-128.
15 Ikezawa Y,Sakakibara Konishi J,Mizugaki H,et al.Inhibition of Notch and HIF enhances the antitumor effect of radiation in Notch expressing lung cancer[J].Cancer Res,2014,74(19):3937-3945.
16 Vinson KE,George DC,Fender AW,et al.The Notch pathway in colorectal cancer[J].Int J Cancer,2016,138(8):1835-1842.
17 陈杰,侯恩存.贝伐单抗联合XELOX方案治疗转移性结直肠癌的研究进展[J].实用肿瘤学杂志,2015,29(2):157-161.
18 Patel NS,Li JL,Generali D,et al.Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function[J].Cancer Res,2005,65(19):8690-8697.
19 Jubb AM,Turley H,Moeller HC,et al.Expression of delta-like ligand 4(Dll4)and markers of hypoxia in colon cancer[J].Brit J Cancer,2009,101(10):1749-1757.
20 Wu W,Wang X,Cheng A,et al.Dysregulation and crosstalk of cellular signaling pathways in colon carcinogenesis[J].Crit Rev Oncol Hematol,2013,86(3):251-277.
21 Zhang Y,Li B,Ji ZZ,et al.Notch1 regulates the growth of human colon cancers[J].Cancer,2010,116(22):5207-5218.
22 Chu D,Zhang Z,Zhou Y,et al.Notch1 and Notch2 have opposite prognostic effects on patients with colorectal cancer[J].Ann Oncol,2011,22(22):2440-2447.
23 Yen WC,Fischer MM,Axelrod F,et al.Targeting Notch signaling with a Notch2/Notch3 antagonist(Tarextumab)inhibits tumor growth and decreases tumor-initiating cell frequency[J].Clin Cancer Res,2015,21(9):2084-2095.
24 Groeneweg JW,Foster R,Growdon WB,et al.Notch signaling in serous ovarian cancer[J].J Ovarian Res,2014,4(7):95-107.
25 Lu J,Xia Y,Chen K,et al.Oncogenic role of the Notch pathway in primary liver cancer[J].Oncol Lett,2016,12(1):3-10.
26 Olsauskaskuprys R,Zlobin A,Osipo C.Gamma secretase inhibitors of Notch signaling[J].Oncotargets Ther,2013,6(6):943-955.
27 Takebe N,Nguyen D,Yang SX.Targeting notch signaling pathway in cancer:clinical development advances and challenges[J].Pharmacology Therapeutics,2013,141(2):140-149.
28 Hassan KA,Wang L,Korkaya H,et al.Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma[J].Clin Cancer Res,2013,19(8):1972-1980.

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Research progress in the Notch pathway in malignant tumors

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